New Modes of Metallocycle Reactivity

本项目属于无机、生物无机和有机金属化学专业，属于有机金属化学领域。该项目的重点是金属环配合物，它在许多有机金属反应中起着重要的中间体作用，如炔烃的环加成和烯烃的复分解。目标是发展新的过渡金属介导的环化涉及一个碳部分和两个等效的炔。这样的反应与Pauson-Khand反应有着根本的不同，最终将允许新的分子内环化，其中无环前体转化为融合的三环系统。一般方法将涉及通过在金属环戊二烯配合物上引入碳或碳前体来形成金属环戊二烯-碳中间体。或者由已经含有碳前体的络合物形成金属环。所研究类型的高效环加成反应的发展将大大简化各种生物重要有机化合物的实验室合成。

This project in the Inorganic, Bioinorganic and Organometallic Chemistry Program is in the area of organometallic chemistry. The focus of the project is metallacycle complexes which play an important role as intermediates in numerous organometallic reactions such as cycloadditions of alkynes and olefin metathesis. The goal is the development of new transition metal-mediated cyclizations involving a carbene moiety and two equivalents of alkyne. Such a reaction is fundamentally different than the Pauson-Khand reaction and would ultimately allow for novel intramolecular cyclizations in which acyclic precursors are converted to fused tricyclic ring systems. The general approach will involve the formation of a metallacyclopentadiene-carbene intermediate either by the introduction of a carbene or carbene precursor onto a metallacyclopentadiene complex, or by the formation of a metallacycle from a complex already containing a carbene precursor. The development of an efficient cycloaddition reaction of the type under investigation would simplify greatly the laboratory synthesis of a wide variety of biologically important organic compounds.