Application of the Solvatochromic Comparison Method to Chromatographic Retention and Selectivity

化学部分析和表面化学项目研究溶剂化的基本原理，即添加剂与液体的相互作用。溶剂化性质影响反应速度和反应过程。当两种或两种以上的溶剂相互作用时，组分的分离是基于竞争性溶剂化性质。卡尔教授一直在发展对溶剂化的一般描述，这项工作扩展了他早期的探索。溶剂化性质是根据Kamlet-Taft偶极标度、氢键酸度和碱度来组织的。将使用气相色谱和液相色谱来测量溶剂化参数，然后将根据先前测量的参数的知识来评估新的色谱柱。将扩大反相液相色谱表征的范围。将建立作为酸碱度参数的函数的溶剂化自由能标度。

This project in the Analytical and Surface Chemistry Program of the Chemistry Division studies the fundamentals of solvation, the interaction of additives with liquids. Solvation properties affect reaction rates and the course of reactions. When two or more solvents interact, separation of components is based on competitive solvation properties. Prof. Carr has been developing general descriptions of solvation, and this work extends his earlier explorations. Solvation properties are organized based on Kamlet-Taft scales of dipolarity, hydrogen bond acidity, and basicity. Gas and liquid chromatography will be used to measure solvation parameters, and then new chromatography columns will be evaluated based on knowledge of the previously measured parameters. Extension to characterization of reversed phase liquid chromatography will be made. Free energy scales for solvation as a function of acidity and basicity parameters will be established.