Mathematical Sciences: Theories of Ionic Movement in Biological Channels

这组研究人员将研究生物通道中离子运动的理论模型。理论模型将与数据结合使用，以建议新的实验，并修改现有模型。这些模型的目标是更好地理解生物学。许多细胞的许多功能是由单独的通道蛋白决定的，这些蛋白控制着物质和信号在原本相当不透膜的膜上的移动。该小组将使用溶液中离子的布朗运动理论来分析已知的离子在通道中运动的特性。该小组希望了解和预测描述各种类型的单个开放通道的电导、电流-电压关系和选择性的大量实验数据。

This group of investigators will study theoretical models of ionic movement in biological channels. The theoretical models will be used in conjunction with data, to suggest new experiments, and to modify the existing model. The goal of these models is to better understand the biology. Many functions of many cells are determined by individual channel proteins, which control the movement of substances and signals across otherwise quite impermeable membranes. This group will use the theory of Brownian motion of ions in solution to analyze the experimentally known properties of ion movement in channels. The group hopes to understand and predict the large mass of experimental data describing conductance, current-voltage relations, and selectivity of single open channels of various types.