Mathematical Sciences: Mathematical Analysis of Receptor Aggregation on Cell Surfaces and its Effects on Cell Function

主要研究者将与 细胞领域的实验和理论生物学家 表面受体 生物细胞感知环境 主要通过细胞表面受体与 特异性细胞外配体。 这些分子间的相互作用 作为信号，启动细胞对激素的反应， 神经递质、免疫反应介质和其它分子。 计划的工作是数学的组成部分， 理论/实验合作，旨在确定 特定的细胞信号和反应途径。 这些模型 这对于理解生物学至关重要，因为 机制不能直接观察到。 的数学工具 将涉及空间数据的分析。 首席研究员将与 细胞领域的实验和理论生物学家 表面受体 计划的工作是数学 这一合作的组成部分，旨在确定 特定的细胞信号和反应途径。 这些模型 这对于理解生物学至关重要，因为 机制不能直接观察到。 的数学工具 将涉及空间数据的分析。

The principal investigator will work in collaboration with both experimental and theoretical biologists in the area of cell surface receptors. Biological cells sense their environment primarily through the interaction of cell surface receptors with specific extracellular ligands. These molecular interactions serve as signals, initiating cell responses to hormones, neurotransmitters, immune response mediators and other molecules. The planned work is the mathematical component of theoretical/experimental collaborations aimed at identifying particular cell signals and response pathways. These models are essential for the understanding of the biology, because the mechanisms cannot be observed directly. The mathematical tools will involve the analysis of spatial data. The principal investigator will work in collaboration with both experimental and theoretical biologists in the area of cell surface receptors. The planned work is the mathematical component of this collaboration which is aimed at identifying particular cell signals and response pathways. These models are essential for the understanding of the biology, because the mechanisms cannot be observed directly. The mathematical tools will involve the analysis of spatial data.