Understanding Metal-Catalyzed High Pressure Carbonylations of Organic Compounds

韦恩博士Gladfelter，化学系，大学 明尼苏达州，将调查的机制， 金属催化的有机化合物的羰基化。 支持 对于这种环境友好的化学合成和 加工项目将由无机， 生物无机和有机化学程序。 格拉德费尔特 将与Catalytica的John Grate博士合作。 原位红外 和NMR方法将用于监测羰基化反应 硝基芳族化合物形成异氰酸酯。 催化剂前体 将是Ru3（CO）12和各种羰基钌， 膦和亚磷酸酯配体。 工作的针对性， 环境友好的合成是反应提供了一个 避免使用光气（一种危险中间体）的方法 异氰酸酯的合成。 更多的研究将集中在 这些催化剂和相关催化剂在不对称 极性化合物的合成和氢化。 %%% 在化学工业中， 工业，特别是在绝缘生产中。 的 目前的聚氨酯路线需要将 硝基芳族化合物对异氰酸酯化合物具有高毒性， 物种，光气，在此期间大量使用 转换. 一种新的催化方法， 研究光气。 目前，该方法显示出很大的 承诺，但需要了解它如何运作。 Catalytica是一家总部位于加州的公司， 商业化经济和环境有利 石油炼制、能源和 化工.

Dr. Wayne L. Gladfelter of the Chemistry Department, University of Minnesota, will investigate the mechanisms of metal-catalyzed carbonylations of organic compounds. Support for this Environmentally Benign Chemical Synthesis and Processing project will be provided by the Inorganic, Bioinorganic, and Organometallic Chemistry program. Gladfelter will collaborate with Dr. John Grate of Catalytica. In situ IR and NMR methods will be used to monitor carbonylation reactions of nitroaromatics to form isocyanates. The catalyst precursors will be Ru3(CO)12 and various ruthenium carbonyls having phosphine and phosphite ligands. The pertinence of the work to Environmentally Benign Synthesis is that the reactions afford a method to bypass the use of phosgene (a hazardous intermediate) in the synthesis of isocyanates. Additional studies will focus on the use of these and related catalysts in asymmetric synthesis and hydrogenation of polar compounds. %%% Polyurethanes are produced in great quantity in the chemical industry, especially in the production of insulation. The present route to polyurethanes entails the conversion of nitroaromatic to isocyanate compounds with a highly toxic species, phosgene, being used in great amounts during this conversion. A new catalytic method that bypasses the use of phosgene is to be studied. At present the method shows great promise, but much needs to be learned about how it functions. Catalytica is a California-based company that creates and commercializes economic and environmentally advantageous catalytic technologies for the petroleum refining, energy, and chemical industries.