Purchase of a High-Resolution LC/MS/MS System

通过化学研究仪器和设施：部门多用户仪器采购（CRIF：MU）计划的这一奖项，明尼苏达大学化学系将获得高分辨率液相色谱仪/质谱仪（LC/MS/MS）。将受益于这一仪器的研究项目包括：a）环境中的药物污染物; B）亚细胞定位; c）非血红素铁酶的氧活化机制; d）蛋白质异戊二烯化; e）使用脂肪酸结合蛋白设计反应催化剂; e）生物活性天然产物的合成;和f）生物系统中的蛋白质-核酸相互作用。液相色谱-质谱检测是用于分离和分析复杂混合物的极其强大的技术。此次收购将增加获得质谱仪器的研究人员和研究生和本科生的LC/MS/MS技术纳入研究和教学，以及提供访问几个主要的本科院校。 这些研究将在许多领域产生坚实的影响，从合成有机，天然产品和生物无机化学到生物和环境分析。

With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multiuser Instrument Acquisition (CRIF:MU) Program, the Department of Chemistry the University of Minnesota will acquire a high-resolution liquid chromatograph/mass spectrometer (LC/MS/MS). Research projects that will benefit from this instrumentation include studies on a) pharmaceutical pollutants in the environment; b) subcellular localization; c) mechanisms of oxygen activation by nonheme iron enzymes; d) protein prenylation; e) design of reaction catalysts using fatty acid binding proteins; e) synthesis of bioactive natural products; and f) protein-nucleic acid interactions in biological systems.Liquid chromatography with mass spectrometric detection is an extremely powerful technique used for the separation and analysis of complex mixtures. This acquisition will increase access to mass spectrometry instrumentation both to researchers and to graduate and undergraduate students by incorporation of LC/MS/MS techniques into both research and teaching, as well as providing access to several primarily undergraduate institutions. These studies will have a solid impact in a number of areas, ranging from synthetic organic, natural products and bioinorganic chemistry to biological and environmental analyses.