Purchase of a High-Resolution LC/MS/MS System

购买高分辨率 LC/MS/MS 系统

• 批准号: 0541709
• 负责人: Wayne Gladfelter
• 金额: $ 29.9万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2009-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0541709&HistoricalAwards=false
• 关键词: Purchase; Resolution; LC; MS; System

With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multiuser Instrument Acquisition (CRIF:MU) Program, the Department of Chemistry the University of Minnesota will acquire a high-resolution liquid chromatograph/mass spectrometer (LC/MS/MS). Research projects that will benefit from this instrumentation include studies on a) pharmaceutical pollutants in the environment; b) subcellular localization; c) mechanisms of oxygen activation by nonheme iron enzymes; d) protein prenylation; e) design of reaction catalysts using fatty acid binding proteins; e) synthesis of bioactive natural products; and f) protein-nucleic acid interactions in biological systems.Liquid chromatography with mass spectrometric detection is an extremely powerful technique used for the separation and analysis of complex mixtures. This acquisition will increase access to mass spectrometry instrumentation both to researchers and to graduate and undergraduate students by incorporation of LC/MS/MS techniques into both research and teaching, as well as providing access to several primarily undergraduate institutions. These studies will have a solid impact in a number of areas, ranging from synthetic organic, natural products and bioinorganic chemistry to biological and environmental analyses.

根据化学研究仪器和设施：部门多用户仪器采购（CRIF:MU）计划，明尼苏达大学化学系将获得一台高分辨率液相色谱仪/质谱仪。将受益于该仪器的研究项目包括：a)环境中的药物污染物的研究；B)亚细胞定位；C)非血红素铁酶激活氧的机制；D)蛋白前酰化；E)利用脂肪酸结合蛋白设计反应催化剂；E)生物活性天然产物的合成；f)生物系统中蛋白质与核酸的相互作用。液相色谱与质谱检测是一种非常强大的技术，用于分离和分析复杂的混合物。此次收购将通过将LC/MS/MS技术结合到研究和教学中，增加研究人员、研究生和本科生使用质谱仪器的机会，并为几所主要的本科院校提供访问机会。这些研究将在许多领域产生坚实的影响，从合成有机、天然产品和生物无机化学到生物和环境分析。