Synthetic and Mechanistic Studies on Catalytic Asymmetric Reaction of Organosilanes

本研究的重点是使用硅杂环丁烷基试剂 和手性刘易斯碱。 共同的主题是追求 作为组织节点的六配位硅物质 亲核试剂、亲电试剂和手性催化剂的组合 不对称变换的。 烯氧基硅杂环丁烷将用于 促进羟醛、迈克尔、亨利和阿布拉莫夫反应和硅杂环丁烷 将用于广泛的有机硅转化。 另一 部分研究集中在配体加速催化， 三氯硅基试剂 有了这个基于成就的更新奖，合成有机 该项目支持Scott E.丹麦 伊利诺伊大学化学系。 丹麦教授 他将把工作重点放在开发新的催化， 不对称变换 这项研究将涉及有机硅 具有六配位硅的化合物和手性刘易斯碱 物种是关键组成部分。

The focus of this research is the use of silacyclobutane based reagents and chiral Lewis bases. The common theme is the pursuit of hexacoordinate silicon species as organizational nodes for bringing together combinations of nucleophile, electrophile and chiral catalyst for asymmetric transformations. Enoxysilacyclobutanes will be used to promote aldol, Michael, Henry and Abramov reactions and silacyclobutanes will be used in a broad range of organosilicon transformations. Another part of the research focuses on ligand-accelerated catalysis by the use of trichlorosilyl-based reagents. With this accomplishment based renewal award, the Synthetic Organic Program is supporting the research of Dr. Scott E. Denmark of the Department of Chemistry at the University of Illinois. Professor Denmark will focus his work on developing new methodology for catalytic, asymmetric transformations. The research will involve organosilicon compounds and chiral Lewis bases that possess hexacoordinate silicon species as the key component.