A “Goldilocks” live attenuated poultry vaccine for Infectious Coryza

该项目旨在使用减毒活疫苗方法开发一种安全有效的鸡传染性鼻炎疫苗。鸡传染性鼻炎是鸡的一种急性呼吸道疾病，由细菌性副伤寒杆菌引起。传染性鼻炎可以通过适当的生物安全措施加以控制，这在澳大利亚的情况下迄今是成功的。然而，在美国、欧洲和其他赤道地区，传染性Coryza仍然是一个悬而未决的问题。该项目的预期结果是一种跨血清保护性疫苗，以防止流行国家使用的传染性鼻炎，并作为一项生物安全措施，保护澳大利亚的家禽业免受这种疾病的入侵。

This project aims to develop a safe and effective vaccine for Infectious Coryza using a live-attenuated vaccine approach. Infectious coryza is an acute respiratory disease of chickens and is caused by the bacterial pathogen, Avibacterium paragallinarum. Infectious Coryza can be controlled by appropriate biosecurity practises and this has been successful in the Australian context to date. However, in the USA, Europe and other equatorial regions, infectious Coryza remains an unsolved problem. The expected outcome of this project is a cross-serovar protective vaccine to prevent infectious coryza for use in endemic countries and to act as a biosecurity measure to protect Australia's poultry industry against an incursion of this disease.