D2 Symmetric Catalysts in Asymmetric Synthesis

本论文的研究重点是D2对称催化剂的制备 通过控制络合物中简单手性配体的排列 而不是精心设计D2对称的配体。 催化剂 将在不对称环丙烷化、氮丙啶化和 环氧化 分子间C-H插入和3 + 2环化 将详细研究乙烯基卡宾和富电子烯烃。 有了这个更新奖，有机和高分子化学计划 支持Huw M博士的研究。L.戴维斯 化学在SUNY-Buffalo。 戴维斯教授将把工作重点放在 设计金属催化的不对称转化。 的方法 并且所得手性产物具有用于 制备具有有趣生物学特性的分子。

The focus of this research is the preparation of D2 symmetric catalysts by control of the arrangement of simple chiral ligands within a complex rather than designing elaborate ligands of D2 symmetry. The catalysts will be evaluated in asymmetric cyclopropanations, aziridinations and epoxidations. Intermolecular C-H insertions and 3 + 2 annulations using vinylcarbenoids and electron rich alkenes will be studied in detail. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Huw M. L. Davies of the Department of Chemistry at SUNY-Buffalo. Professor Davies will focus his work on designing metal catalyzed asymmetric transformations. The methodology and the resulting chiral products have potential for use in the preparation of molecules with interesting biological properties.