Upgrade of a 500 MHz Nuclear Magnetic Resonance Spectrometer

这份来自化学研究仪器和设施（CRIF）项目的合同将帮助亚利桑那州立大学化学和生物化学系购买核磁共振（NMR）光谱仪控制台。控制台将为该部门提供升级的500 MHz核磁共振光谱仪。这种设备将加强若干领域的研究，例如：(1)研究蛋白质损伤和修复DNA的基本过程；(2)开发能够监测单个蛋白质和蛋白质/DNA分子构象变化的光学探针；(3)对肌肉细胞具有持久毒性作用的蛇毒蛋白质的结构和机制研究；(4)可导致DNA选择性断裂的化学物质的机制研究；(5)参与免疫应答的糖蛋白结构的确定。核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果在聚合物、催化和生物学等领域是有用的。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry and Biochemistry at Arizona State University to purchase a nuclear magnetic resonance (NMR) spectrometer console. The console will provide the department with an upgraded 500 MHz NMR spectrometer.This equipment will enhance research in a number of areas such as the following: (1) the study of fundamental processes involved in damage and repair of DNA by proteins, (2) the development of optical probes capable of monitoring conformational changes in single protein and protein/DNA molecules, (3) structural and mechanistic studies of proteins from snake venoms that have long-lasting toxic action on muscle cells, (4) mechanistic studies of chemicals that can lead to selective fragmentation of DNA, and (5)structure determination of glycoproteins that are involved in immune response. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.