Capillary Electrophoresis in the Undergraduate Curriculum in Chemistry and Biological Chemistry

毛细管电泳将被纳入贝茨学院化学和生物化学本科课程。电泳技术在化学分析中越来越重要，这在很大程度上是由于化学和生物学界面工作的增加。因此，应该向本科阶段的学生介绍电泳的理论和实践方面，特别是毛细管电泳。该仪器将用于与分析和生物化学课程相关的本科实验室。这些课程的实验经验是基于项目的，因此将加入到课程中使用毛细管电泳的实验范围是雄心勃勃的。将开展的项目类型包括脑组织中神经肽的分析、血液中的血红蛋白变异、人类DNA的DNA限制性片段分析和蛋白质制图，以确认通过定点诱变进行蛋白质修饰的有效性。毛细管电泳将补充分析化学和生物化学本科课程中已经提供的方法、技术和经验。毛细管电泳设备也将有利于学生在生物和化学的界面进行研究项目。

Capillary electrophoresis will be incorporated into the undergraduate curriculum in chemistry and biochemistry at Bates College. Electrophoretic techniques are of growing importance in chemical analysis, in large part because of the increase in work at the interface of chemistry and biology. Students at the undergraduate level should therefore be introduced to the theoretical and practical aspects of electrophoresis, and particularly capillary electrophoresis. The instrumentation will be utilized in undergraduate laboratories associated with courses in analytical and biological chemistry. The lab experiences in these courses are project-based, so the experiments that will be added to the curriculum utilizing capillary electrophoresis are ambitious in scope. Examples of the types of projects that will be undertaken include the analysis of neuropeptides in brain tissue, hemoglobin variants in blood, DNA restriction fragment analysis of human DNA, and protein mapping to confirm the effectiveness of protein modification through site selected mutagenesis. Capillary electrophoresis will complement the methods, techniques and experiences that are already provided in undergraduate courses in analytical and biological chemistry. Capillary electrophoresis equipment will also be beneficial to students conducting research projects at the interface of biology and chemistry.