Microbial Genome Sequencing: Genome Sequence of Magnaporthe Grisea

稻瘟病是由稻瘟病菌引起的一种严重威胁世界粮食安全的病害。几十年的深入研究已经证明，该真菌非常适合于遗传和分子遗传操作，使其成为阐明植物致病基础的主要模型，包括与感染相关的形态发生和品种/寄主范围特异性。Magnaporthe研究界已经成立了一个国际联盟，目标是获得这种真菌的完整基因组序列。该社区还开发了许多生物资源和工具，以立即利用该序列。该项目代表了北卡罗来纳州立大学和怀特黑德研究所-基因组研究中心之间的合作伙伴关系，以使用全基因组鸟枪法生成和组装整个基因组，并执行自动注释。这一序列以注释形式迅速提供，将立即为学生的研究和教育整合提供新的机会。这些数据将促进发现基因和潜在的抗真菌靶点，允许重建途径，提供用于遗传和功能研究的序列锚定克隆路径，并使比较基因组学方法得以开始。此外，这些数据将为发现和设计新的无害环境的战略提供基础，以更有效地管理这种和其他真菌疾病。这是一个微生物基因组测序奖，通过国家科学基金会和农业部未来农业和食品系统倡议之间的合作活动提供资金。该奖项是稻瘟病菌基因组测序项目的一部分。另一部分由美国农业部提供资金。

Rice blast disease, caused by the fungal pathogen Magnaporthe grisea, is a major threat to food security worldwide. Decades of intense investigation have proven the fungus to be eminently suitable for genetic and molecular genetic manipulation, making it the primary model for elucidating the basis of phytopathogenesis, including infection related morphogenesis and cultivar/host range specificity. The Magnaporthe research community has established an international consortium with the goal of obtaining a complete genome sequence of the fungus. The community has also developed numerous biological resources and tools to take immediate advantage of the sequence. This project represents a partnership between North Carolina State University and the Whitehead Institute-Center for Genome Research to generate and assemble the entire genome using a whole genome shotgun approach and to perform automated annotation. The rapid availability of this sequence in an annotated form will immediately provide new opportunities for integrating research and education of students. The data will promote the discovery of genes and potential anti-fungal targets, permit reconstruction of pathways, provide sequence-anchored clone paths for use in genetic and functional studies, and enable comparative genomic approaches to commence. Moreover, the data will provide the foundation for the discovery and design of novel environmentally sound strategies to more effectively manage this and other fungal diseases. This is a Microbial Genome Sequencing Award funded through a collaborative activity between the National Science Foundation and the Department of Agriculture Initiative for Future Agriculture and Food Systems. This award represents one portion of the Magnaporthe grisea genome sequencing project. The other portion is being funded by the USDA.