Novel Carbon Media for Separation Science

俄亥俄州立大学的Susan Olesik教授在分析和表面化学项目的支持下，开发了能够分离结构差异最小的化合物的色谱介质。近年来对玻璃碳（GC）的保留机制的研究表明，玻璃碳可以通过不同的保留机制与极性和非极性分析物发生强烈的相互作用。因此，玻化碳的色谱应用得到了极大的扩展。此外，固体吸附剂通常是分离结构差异最小的化合物的很好的候选者。由于聚合物前驱体和生产方法的原因，目前只有一种商业上可用的玻璃碳材料用于化合物的分离，并且仅限于多孔颗粒的配置。新的前驱体聚合物，二乙基聚合物，可以在低温下以最小的重量损失生产玻璃碳。这些前驱体聚合物也很容易溶解在有机溶剂中，允许生产连续的低温玻璃碳薄膜。此外，微晶尺寸和石墨化程度随薄膜加工温度的变化而变化。此外，低温玻璃碳（LTGC）表面可以制成包括非碳原子共价结合在其结构中。这些制备的色谱介质在包括药物在内的大量化学品的分离和纯化方面具有潜在的应用。本工作将研究使用精选二乙基聚合物制备的低温玻璃碳（LTGC）的表面化学性质，并开发基于表面化学的新型选择性色谱介质。ltgc具有独特的色谱选择性和广泛的应用前景。纯碳LTGC，全氟LTGC和含氮LTGC薄膜将被表征用于液相色谱。新的GC结构，特别是无孔LTGC颗粒，将与薄膜介质进行比较。

The project of Professor Susan Olesik of Ohio State University, supported by the Analytical and Surface Chemistry program, is to develop chromatographic media capable of separating compounds that differ minimally in their structure. Recent studies on the mechanisms of retention on glassy carbon (GC) have shown that glassy carbon is capable of interacting strongly with both polar and nonpolar analytes through different retention mechanisms. Accordingly the chromatographic applications of glassy carbon have expanded substantially. Also, solid adsorbents are typically very good candidates for the separation of compounds that differ minimally in structure. Due to the polymer precursor and the method of production, there is presently only one commercially-available glassy carbon material for the separation of compounds and it is limited to the configuration of porous particles. New precursor polymers, diacetylenic polymers, allow the production of glassy carbon at low temperatures with minimal weight loss. These precursor polymers are also readily soluble in organic solvents allowing the production of continuous low temperature glassy carbon films. In addition, the microcrystallite size and the extent of graphitization can be varied with film processing temperatures. Furthermore, low temperature glassy carbon (LTGC) surfaces can be made that include noncarbon atoms covalently bound in its structure.Fabricated chromatographic media such as these have potential applications to the separation and purification of a large number of chemicals, including pharmaceuticals. This work will study the surface chemistry of the low temperature glassy carbons (LTGC) produced using select diacetylenic polymers and will develop new selective chromatographic media based on the surface chemistry. LTGCs are expected to be distinctive and should provide unique chromatographic selectivity and extensive applications. Pure carbon LTGC, perfluorinated LTGC, and nitrogen-containing LTGC films will be characterized for use in liquid chromatography. New configurations of GC, specifically nonporous LTGC particles, will be compared to the thin film media.