US-Germany Cooperative Research: Stochastic Phase Resetting in Oscillatory Neurons

该奖项支持PI，共同PI和密苏里大学圣路易斯市的研究生。Louis与德国Juelich研究中心药物研究所的Peter Tass合作。联合研究将结合德国组对帕金森病深部脑刺激治疗随机同步和去同步机制的理论和实验研究，以及美国组对白鲟电感受器随机同步和相位重置的实验电生理和理论建模。合作的具体目标是了解控制噪声振荡神经元同步的一般机制，并验证由德国小组开发的通过深部脑刺激治疗帕金森病患者的新刺激方案的有效性和神经基础。该项目还有一个教育目的。该项目将使参与的研究生受益于在另一个国家进行研究。他们将在学习重要的新技术技能的同时，提高对周围世界的欣赏。

0233264NeimanThis award supports the PI, co-PI, and graduate students from the University of Missouri-St. Louis in a collaboration with Peter Tass of the Institute for Medicines at the Research Center Juelich, Germany. The joint research effort will combine theoretical and experimental studies of mechanisms of stochastic synchronization and de-synchronization for deep brain stimulation therapy of Parkinson's disease by the German group and experimental electrophysiological and theoretical modeling of stochastic synchronization and phase resetting in electroreceptors of paddlefish by the US group. The specific goal of the collaboration is to understand general mechanisms for controlling synchronization in noisy oscillating neurons and to validate the effectiveness and neural basis of novel stimulus protocols developed by the German group for treating Parkinson's patients by deep brain stimulation.The project also has an educational objective. The project will allow the graduate students involved to benefit from performing research in another country. They will develop a heightened appreciation of the world around them while also learning important new technical skills.