Acquisition of a mass spectrometer for research and teaching

在主要研究仪器(MRI)计划的这一奖项下，纽约州立大学城市学院化学系将获得飞行时间质谱仪。该仪器将支持的研究项目包括a)金属催化和金属催化合成新型核苷实体、致癌物-核苷加合物和定点修饰DNA的研究；b)选择性乙烯基和芳基氟化反应、特定氟化烃及其代谢物的合成、氟对构象和生物调节的研究；c)有机外源化合物在环境中的去向和相关反应机理的阐明；d)配体-蛋白质相互作用以及合成类药物分子的研究；e)具有医学意义的整体膜蛋白的结构研究；d)基于呋喃糖基的新型烯二炔类抗生素类似物的合成和研究。质谱仪(MS)是一种用于探测大量有机、生物有机和有机金属分子的内部结构细节和获得其分子组成的技术。这些研究的结果将对包括环境化学和合成化学在内的许多领域产生影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at CUNY City College will acquire a time-of-flight mass spectrometer. Research programs that will be supported by this instrument include a) metal catalysis and metal catalyzed synthesis of novel nucleoside entities, carcinogen-nucleoside adducts and studies on site-specifically modified DNA; b) selective vinyl and aryl fluorination, synthesis of specifically fluorinated hydrocarbons and their metabolites, studies of conformational and biological modulation by fluorine; c) fate of organic xenobiotics in the environment and elucidation of relevant reaction mechanisms; d) studies on ligand-protein interactions as well as synthetic drug-like molecules; e) structural studies of integral membrane proteins of medical relevance; and d) synthesis and studies of furanose-based novel ene-diyne antibiotic analogs. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The results from these studies will have an impact in a number of areas including environmental chemistry and synthetic chemistry.