Synthetic Methods Based on Nickel Enolates

本研究的重点涉及四个目标：第一，开发涉及金属内酯框架内烯醇化镍烷基化的催化过程。 第二，开展烯醛和炔的[3+2]烷基化环加成反应的全合成应用。 第三，开发共轭加成程序，不需要预先形成的有机金属亲核试剂。第四，研究有机锌和相关物种在加速镍催化过程中的作用。 有了这个奖项，有机和高分子化学计划支持博士约翰蒙哥马利在化学系在韦恩州立大学的研究。 教授蒙哥马利将专注于他的工作，涉及镍烯醇化物的生成和功能化的新工艺的发展。 该研究将推动镍催化、共轭加成化学和过渡金属烯醇化物化学的发展。 该项目有可能在制药行业产生更广泛的影响，该项目是本科生、研究生和博士后的良好培训基地。 将强调将代表性不足的少数群体纳入该项目。

The focus of this research involves four goals: First, to develop catalytic processes that involve the alkylation of nickel enolates within a metallacycle framework. Second, to develop total synthesis applications of [3+2] alkylative cycloaddition of enals and alkynes. Third, to develop conjugate addition procedures that do not require preformed organometallic nucleophiles. Fourth, to study the role of organozincs and related species in accelerating the rate of nickel-catalyzed processes. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. John Montgomery in the Department of Chemistry at Wayne State University. Professor Montgomery will focus his work on development of new processes that involve the generation and functionalization of nickel enolates. The research will advance the fields of nickel catalysis, conjugate addition chemistry and transition metal enolate chemistry in general. The project has potential for broader impact in the pharmaceutical industry and the project serves as an excellent training ground for undergraduates, graduate students and postdoctorals. The inclusion of underrepresented minorities to the project will be stressed.