EMSW21-RTG, Biodynamics at Boston University

该项目将促进建立和支持一个学者社区，从本科生到教师，在动力系统和生物应用之间的接口工作。关注的三个主要领域是：1。具有多个长度和时间尺度的系统分析，包括在模式形成中的应用；2. 数学神经科学，包括处理小网络的分析方法和降维技术；3. 基因调控网络，包括RNA开关、转录破裂和可编程细胞的发展。这些领域对健康和医学问题有重要的应用。该项目将建立在生物动力学中心以前的研究和培训经验的基础上，由首席研究员和其他一位高级教员共同指导。受训者将是博士生和博士后，他们将参加各种正式和非正式的活动，包括特别研讨会、工作组、小型专题讨论会、实验室工作、期刊俱乐部和社会活动，这将使他们能够获得以跨学科方式工作所需的多种科学文化。博士预科生将来自数学系或生物医学工程系；博士后助理将从广泛的背景中抽取，重点是应用数学。除了他们的研究活动，学员将获得不同层次的教学经验。数学系的教师和学员将参与其他系（包括生物学）本科生的跨学科新课程建设；教员将指导受训人员教授新课程。

This project will advance the creation and support of a community of scholars, from undergraduate to faculty, working at the interfaces among dynamical systems and biological applications. The three main areas of focus are: 1. Analysis of systems with multiple length and time scales, including applications to pattern formation; 2. Mathematical neuroscience, including analytical methods for working with small networks and reduction of dimension techniques; 3. Gene regulatory networks, including the development of RNA switches, transcriptional bursting and programmable cells. These areas have major applications to issues concerning health and medicine. The project will build on the previous research and training experience of the Center for BioDynamics, co-directed by the Principal Investigator and one of the other senior faculty members. Trainees will be pre- and post-doctoral students who will take part in a wide variety of formal and informal activities, including special seminars, working groups, mini-symposia, laboratory work, journal clubs and social events, which will enable them to acquire the multiple scientific cultures needed to work in a trans-disciplinary manner. The pre-doctoral students will be from the departments of Mathematics or Biomedical Engineering; the postdoctoral associates will be drawn from a wide range of backgrounds, with a focus on applied math. In addition to their research activities, trainees will obtain experience teaching at different levels. Math department faculty and trainees will be involved in the construction of new interdisciplinary curricula for undergraduates in other departments, including Biology; the faculty will mentor the trainees in teaching the new curricula.