"IDBR:" Development of High Speed Electronic-Readout Based Nano-Bio-Mechanical System

该奖项是因为开发了一种Bio-SNFUH：一种在生理条件下使用扫描近场超声全息术(SNFUH)结合样品表面扫描探针显微镜对软生物样品进行无损成像的仪器。Bio-SNFUH将能够对细胞和组织中埋藏和嵌入的亚结构进行非破坏性纳米级三维断层扫描。该项目将结合研究人员对嵌入MOSFET的微悬臂梁的创新与芯片上集成的锁定和电子读出，使Bio-SNFUH成为一种并行和高通量的成像工具包，能够对软结构和生物结构进行快速扫描和快速分析。除了该仪器的科学影响外，Bio-SNFUH将是该大学新的多用户、多方面和24/7访问细微差别中心(西北大学原子和纳米尺度表征实验中心)的组成部分，并将安装在NIFTI(纳米级集成制造、测试和仪器)用户设施中。扩大Bio-SNFUH使用的计划包括短期课程、基于网络的内容交付、广泛的动手培训和教育举措，包括本科生研究项目。

This award is for developing a Bio-SNFUH: an instrument for imaging soft biological samples non-destructively under physiological conditions with Scanning Near-Field Ultrasound Holography (SNFUH) combined with Scanning Probe Microscopy of the sample surface. Bio-SNFUH will be capable of non-destructive nanoscale 3-D tomography of buried and embedded sub-structures in cells and tissues. The project will combine the investigator's innovation of MOSFET-embedded microcantilevers with on-chip integrated lock-in and electronic readout, to make Bio-SNFUH a parallel and high-throughput imaging toolset, capable of fast scanning and rapid analysis of soft and biological structures.In addition to the instrument's scientific impacts, Bio-SNFUH will be an integral part of the university's new multi-user, multifaceted and 24/7 access NUANCE Center (Northwestern University Atomic and Nanoscale Characterization Experimental Center) and will be housed within the NIFTI (Nanoscale Integrated Fabrication, Testing and Instrumentation) user facility. Plans to broaden the usage of Bio-SNFUH include short courses, web-based content delivery, extensive hands-on training and educational initiatives, including undergrad research projects.