Acquisition of a High Resolution Mass Spectrometer

教授迈克尔P.道尔，杰弗里T。作者：David，丹尼尔E. Falvey，Lyle D. Issacs和赫尔曼O.马里兰州大学的Sintim已经提交了一份提案，以响应CRIF：MU的征集，以获得一台高分辨率双扇区质谱仪。它将支持的研究项目与各种研究有关，包括：（i）非天然氨基酸的合成和应用;（ii）用于超分子化学，分子识别和跨膜离子转运受体组装的小分子中间体的表征;（iii）开发高选择性和高效的催化过程，用于合成生物相关化合物;（iv）生物相关化合物的合成。（iv）光诱导电子转移反应的研究和新的高自旋有机物质的产生;（v）用于电子和亲电体沿DNA沿着链迁移的小分子探针的开发;和（vi）铂霉素家族抗生素的全合成。质谱法（MS）用于鉴定样品的化学成分并确定其纯度。 高分辨率质谱仪具有对化合物进行精确元素组成分析的能力。 这使其成为鉴定已知和未知或新化合物的有力工具。 这次收购将有利于本科生和研究生在他们的研究，并在一个新的实验课程开发。 霍华德大学、弗吉尼亚州立大学和天主教大学的学生和教职员工也将使用它来分析样本。

Professors Michael P. Doyle, Jeffrey T. Davis, Daniel E. Falvey, Lyle D. Issacs and Herman O. Sintim of the University of Maryland have submitted a proposal in response to the CRIF: MU solicitation to acquire a high resolution double sector mass spectrometer. The research projects it will support are related to a variety of studies including: (i) synthesis and application of unnatural amino acids; (ii) characterization of small molecule intermediates used in supramolecular chemistry, molecular recognition, and the assembly of receptors for transmembrane ion-transport; (iii) development of highly selective and efficient catalytic processes for the synthesis of biologically relevant compounds; (iv) the study of photo induced electron transfer reactions and the generation of novel high spin organic species; (v) development of small molecule probes for electron and electrophile migration along strands of DNA; and, (vi) total synthesis of antibiotics of the family of Platensimycin. Mass spectrometry (MS) is used to identify the chemical composition of a sample and determine its purity. A high resolution mass spectrometer has the capability of performing accurate elemental composition analysis of compounds. This makes it a powerful tool for identification of known and unknown or new compounds. This acquisition will benefit undergraduate and graduate students in their research and in a new experimental course to be developed. Students and faculty at Howard University Virginia State University and Catholic University will also use it to analyze samples.