RUI: Hypervalent Iodine Chemistry

该项目将继续致力于开发基于高价碘（III）和碘（V）化合物化学的新合成方法，这些化合物是高效和无害环境的氧化剂，在有机合成中有许多应用。虽然高价碘化合物是公认的试剂，但在开发由高价碘促进的新催化反应方面几乎没有取得进展。 以碘代芳烃和过渡金属为助催化剂，过硫酸氢钾为化学计量氧化剂，研究了新型、温和、高效的碘（V）/过渡金属串联催化体系。 其他几个碘芳烃催化的氧化转化，如霍夫曼重排的酰胺胺，制备不饱和羰基化合物从酮，氧化裂解的碳-碳双键，碘（III）催化的对映选择性氧化反应也将进行研究。 还将探索性地寻找新的和潜在有用的高价有机化合物。 此外，该项目的一个重要目标是为BS和MS学生提供高级化学研究的优秀培训，并进一步加强明尼苏达大学杜卢斯的主要本科生研究。有了这个奖项，化学合成计划支持明尼苏达大学杜卢斯化学和生物化学系的Viktor V. Zhdankin教授的研究。 Zhdankin教授的研究工作围绕着基于高价碘化学的简易氧化方法的发展。 这种化学将有助于环境友好的化学合成方法，因为它利用无毒的碘化合物作为催化剂或水溶液中的可回收试剂。 该方法的成功开发将对制药工业的合成产生影响。

This project will continue work on the development of new synthetic methodologies based on the chemistry of hypervalent iodine(III) and iodine(V) compounds, which are efficient and environmentally benign oxidizing reagents with numerous applications in organic synthesis. While hypervalent iodine compounds are well-established reagents, little progress has been made in the development of new catalytic reactions promoted by hypervalent iodine. Studies of new, extremely mild and efficient iodine(V)/transition metal tandem catalytic system for the oxidation of hydrocarbons will be investigated using various aryliodides and transition metals as co-catalysts and Oxone as a stoichiometric oxidant. Several other iodoarene-catalyzed oxidative transformations, such as Hofmann rearrangement of amides to amines, preparation of unsaturated carbonyl compounds from ketones, oxidative cleavage of carbon-carbon double bonds, and the iodine(III)-catalyzed enantioselective oxidations will also be studied. An exploratory search for new and potentially useful hypervalent organic compounds will be also performed. In addition, an important objective of this project is to provide excellent training in advanced chemistry research to BS and MS students and to further strengthen predominantly undergraduate research at University of Minnesota Duluth.With this award, the Chemical Synthesis program is supporting the research of Professor Viktor V. Zhdankin of the Department of Chemistry and Biochemistry at University of Minnesota Duluth. Professor Zhdankin's research efforts revolve around the development of facile oxidative methods based on hypervalent iodine chemistry. Such chemistry will contribute to environmentally benign methods for chemical synthesis as it utilizes non-toxic compounds of iodine as catalysts or recyclable reagents in aqueous solutions. Successful development of the methodology will have an impact on synthesis in the pharmaceutical industry.