RUI: Development of new polyvalent iodine reagents
RUI:新型多价碘试剂的开发
基本信息
- 批准号:1759798
- 负责人:
- 金额:$ 34.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-01 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In this project supported by the Chemical Synthesis Program of the Chemistry Division, Professor Viktor V. Zhdankin of the Department of Chemistry and Biochemistry at University of Minnesota Duluth is developing new classes of oxidizing agents. Oxidizing agents are important tools for the construction of a wide variety of molecules. The approach Professor Zhdankin and his group is developing utilizes polyvalent iodine compounds because they are efficient and environmentally more "friendly" that the reagents currently used. The iodine based systems work because iodine is one of the heaviest elements in the Periodic Table classified as a non-metal. Hence, these more sustainable reagents mimic the structural features and reactivity pattern heavy, frequently toxic transition metals they are being used to replace. It is also important to note that the reagents are new. As such, they can be used to not only replicate existing methods, but also to develop entirely new reactions. The project lies at the interface of organic and inorganic chemistry and it is well suited for undergraduate education as well as for training of scientists at all levels. Professor Zhdankin's group has a long history of providing the highest level of education and training for students underrepresented in science. Professor Zhdankin and his group are pursuing a broad study of new, metal-free, iodine-mediated reactions. In this effort, they are searching for new hypervalent reagents, and they are exploring the new modes of reactivity those reagents enable. Specific objectives of this project include the study of arylbenziodoxaboroles as efficient benzyne precursors, the development of new carbene precursors based on phenolic iodonium salts, the study of arylation reactions with phenolic diaryliodonium salts, and the study of phosphonium-iodonium ylides as reagents for synthesis of trifluoromethyl-substituted alkenes. In a second effort, Professor Zhdankin is searching for stable and potentially useful hypervalent iodine complexes with mesoionic carbenes. The new synthetic methodology based on organohypervalent iodine chemistry is contributing to environmentally benign methods for chemical synthesis as it utilizes non-toxic compounds of iodine as catalysts or recyclable reagents in aqueous solutions. Successful development of this methodology is having an impact on how the synthesis of molecules relevant to the pharmaceutical, chemical, and agricultural industries is approached. This project provides excellent training to students at all levels of education including those from groups historically underrepresented in the sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在这个由化学系化学合成项目支持的项目中,明尼苏达大学杜卢斯化学和生物化学系的Viktor V. Zhdankin教授正在开发新的氧化剂。氧化剂是构建各种分子的重要工具。Zhdankin教授和他的团队正在开发的方法利用多价碘化合物,因为它们比目前使用的试剂更有效,更环保。基于碘的系统工作,因为碘是元素周期表中归类为非金属的最重元素之一。因此,这些更可持续的试剂模拟了它们被用来取代的重的、经常有毒的过渡金属的结构特征和反应模式。还需要注意的是,试剂是新的。因此,它们不仅可以用于复制现有方法,还可以用于开发全新的反应。该项目位于有机和无机化学的界面,非常适合本科教育以及各级科学家的培训。Zhdankin教授的小组在为科学领域代表性不足的学生提供最高水平的教育和培训方面有着悠久的历史。Zhdankin教授和他的团队正在对新的、无金属的、碘介导的反应进行广泛的研究。在这项工作中,他们正在寻找新的超价试剂,并探索这些试剂能够实现的新反应模式。 该项目的具体目标包括研究芳基苯并碘杂硼杂环戊烯作为有效的苯炔前体,开发基于酚碘鎓盐的新卡宾前体,研究与酚二芳基碘鎓盐的芳基化反应,以及研究膦碘鎓叶立德作为合成三氟甲基取代烯烃的试剂。在第二次努力中,Zhdankin教授正在寻找稳定的和潜在有用的高价碘与中离子卡宾的配合物。基于有机高价碘化学的新合成方法有助于环境友好的化学合成方法,因为它利用无毒的碘化合物作为催化剂或水溶液中的可回收试剂。 这种方法的成功开发对如何合成与制药,化学和农业工业相关的分子产生了影响。该项目为各级教育的学生提供了出色的培训,包括那些来自历史上在科学领域代表性不足的群体的学生。该奖项反映了NSF的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(22)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hypervalent Iodine‐Mediated Azidation Reactions
高价碘介导的叠氮化反应
- DOI:10.1002/ejoc.202200754
- 发表时间:2022
- 期刊:
- 影响因子:2.8
- 作者:Mironova, Irina A.;Kirsch, Stefan F.;Zhdankin, Viktor V.;Yoshimura, Akira;Yusubov, Mekhman S.
- 通讯作者:Yusubov, Mekhman S.
Zefirov's reagent and related hypervalent iodine triflates
Zefirov 试剂和相关高价三氟甲磺酸碘
- DOI:10.1016/j.mencom.2021.05.002
- 发表时间:2021
- 期刊:
- 影响因子:1.9
- 作者:Yusubov, Mekhman S.;Zhdankin, Viktor V.
- 通讯作者:Zhdankin, Viktor V.
Hypervalent iodine (V) catalyzed reactions
高价碘 (V) 催化反应
- DOI:10.24820/ark.5550190.p011.800
- 发表时间:2023
- 期刊:
- 影响因子:0.9
- 作者:Soni, Sakshi;Kumar, Vinod;Kikushima, Kotaro;Dohi, Toshifumi;Zhdankin, Viktor V.;Kumar, Ravi
- 通讯作者:Kumar, Ravi
2-Iodoxybenzoic acid ditriflate: the most powerful hypervalent iodine( v ) oxidant
2-碘氧基苯甲酸二三氟甲磺酸盐:最强的高价碘(v)氧化剂
- DOI:10.1039/c9cc04203b
- 发表时间:2019
- 期刊:
- 影响因子:4.9
- 作者:Yusubov, Mekhman S.;Soldatova, Natalia S.;Postnikov, Pavel S.;Valiev, Rashid R.;Yoshimura, Akira;Wirth, Thomas;Nemykin, Victor N.;Zhdankin, Viktor V.
- 通讯作者:Zhdankin, Viktor V.
Introduction to hypervalent iodine chemistry. Part 3
高价碘化学简介。
- DOI:10.24820/ark.5550190.p001.488
- 发表时间:2023
- 期刊:
- 影响因子:0.9
- 作者:Zhdankin, Viktor
- 通讯作者:Zhdankin, Viktor
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Viktor Zhdankin其他文献
Viktor Zhdankin的其他文献
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{{ truncateString('Viktor Zhdankin', 18)}}的其他基金
RUI: Development of New Reagents and Synthetic Methodologies Based on Hypervalent Iodine Chemistry
RUI:基于高价碘化学的新试剂和合成方法的开发
- 批准号:
2243793 - 财政年份:2023
- 资助金额:
$ 34.11万 - 项目类别:
Standard Grant
SusChEM: RUI: Organohypervalent Iodine Chemistry
SusChEM:RUI:有机高价碘化学
- 批准号:
1262479 - 财政年份:2013
- 资助金额:
$ 34.11万 - 项目类别:
Continuing Grant
RUI: Chemistry of Hypervalent Organoiodine Compounds
RUI:高价有机碘化合物的化学
- 批准号:
0702734 - 财政年份:2007
- 资助金额:
$ 34.11万 - 项目类别:
Continuing Grant
Acquisition of High Field NMR Spectrometer
购置高场核磁共振波谱仪
- 批准号:
0416157 - 财政年份:2004
- 资助金额:
$ 34.11万 - 项目类别:
Standard Grant
Organic Chemistry of Hypervalent Compounds
高价化合物的有机化学
- 批准号:
0353541 - 财政年份:2004
- 资助金额:
$ 34.11万 - 项目类别:
Standard Grant
RUI: Organic Chemistry of Hypervalent Compounds
RUI:高价化合物的有机化学
- 批准号:
0101021 - 财政年份:2001
- 资助金额:
$ 34.11万 - 项目类别:
Standard Grant
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