MRI: Acquisition of a 500 MHz NMR Spectrometer for Teaching and Research

1126005GrossFunds被要求购买500 MHz核磁共振来取代纽约大学理工学院非常旧的布鲁克DPX 300 MHz核磁共振？s (NYU-POLY)。该仪器将有两个射频通道，脉冲场梯度，变温能力，两个溶液探针，自动调谐和匹配，和一个自动进样器。目前的核磁共振需要更换，原因如下：1)它很旧，2)它的能力严重有限，3)需要更高的场强提供更大的分散和灵敏度。目前的核磁共振没有脉冲场梯度，也没有能力形成射频脉冲，因此，它不能进行现代二维实验或现代溶剂抑制技术。当代核磁共振方法是必不可少的研究在纽约大学poly。我们现在用的仪器太旧了，备件都没有了，仪器很快就会停止工作。此外，它的灵敏度很差，所要求的核磁共振将提供5倍的灵敏度。提议的500 MHz核磁共振具有高色散和执行现代二维实验的能力，将成为提议PI， Co-PI？在高分子研究所（PRI）、化学与生物科学系、化学与生物工程系、生物工程系，共招收9名高中生、18名本科生、21名硕士、27名博士和5.5名博士后。

1126005GrossFunds are requested to purchase a 500 MHz NMR to replace the very old and Bruker DPX 300 MHz NMR at Polytechnic Institute of New York University?s (NYU-POLY). The instrument will have two radio-frequency channels, pulsed-field gradients, variable-temperature capability, two solution probes with automatic tune and match, and an autosampler. The current NMR needs replacement for the following reasons: i) it is very old, ii) its capabilities are severely limited, iii) the need for greater dispersion and sensitivity provided by higher field strength. The current NMR has no pulse field gradients and no ability to shape radio-frequency pulse and, as such, it cannot perform modern 2D experiments or modern solvent suppression echniques.Contemporary NMR methods are essential to research at NYU-POLY. Our current instrument is so old that spare parts are no longer available and the instrument will soon cease to function. Furthermore, its sensitivity is poor and the requested NMR will provide five times greater sensitivity. The proposed 500 MHz NMR with high dispersion and ability to perform modern 2D experiments will be an essential research tool to the proposal PI, Co-PI?s, their students (in total 9 High School, 18 undergrad, 21 MS, 27 Ph.D. and 5.5 postdoctoral fellows), and other faculty in the Polymer Research Institute (PRI), Departments of Chemical and Biological Sciences, Chemical and Biological Engineering, and Bioengineering.