New Directions in Carbenoid Chemistry

在这个由化学系化学合成计划资助的项目中，埃默里大学化学系的休·M·戴维斯教授将探索以供体/受体卡宾为关键中间体的新合成方法的开发。虽然这种类型的化学已经很好地建立了铑催化剂，但这项研究将定义当银和金作为催化剂时存在的新的合成机会。该项目还将扩大可用于这一化学的可行供体基团的范围，特别强调新型氨基酸的立体选择性合成。在这些研究期间开发的新的合成方法可能成为使技术成为可能，从而影响其他科学领域，如制药和材料科学。该计划将有助于环境友好的化学合成方法，因为关键反应可以在极低的催化剂负载下进行，氮气是唯一的副产品。此外，该项目将为学生提供极好的培训，从本科前到博士后，包括那些在科学界历来代表性不足的学生。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Huw M. Davies of the Department of Chemistry at Emory University will explore the development of new synthetic methods using donor/acceptor carbenoids as the key intermediates. While rhodium catalysts are well established for this type of chemistry, this study will define the new synthetic opportunities that exist when silver and gold are used as catalysts. The project will also expand the range of viable donor groups that can be employed in this chemistry with a particular emphasis on the stereoselective synthesis of novel amino acids. The new synthetic methodologies developed during these studies could become enabling technologies that will impact other fields of science such as pharmaceutical and materials science. The program will contribute to environmentally benign methods for chemical synthesis as the key reactions can be conducted with extremely low catalyst loadings and nitrogen gas is the only by-product. In addition, this project will provide excellent training of students, from pre-undergraduate to post-doctoral, including those from groups historically underrepresented in the sciences.