Unravelling the principles of bilateral brain wiring

该项目旨在研究哺乳动物大脑线路的分子原理，以及微小的变化如何产生复杂的结果。哺乳动物大脑中的神经元必须精确地连接在一起，才能使大脑正常工作。该项目旨在确定控制哺乳动物皮层连接的分子和细胞规则，以确定人类大脑中最大的纤维束——胼胝体是如何进化的。这可能涉及到影响轴突引导的机制的改变，这在胎盘动物和有袋动物之间是不同的。该项目研究了决定交联神经元命运的调控基因网络，轴突引导成分的调控，以及周围脑组织对交联连接发育的影响。

This project seeks to investigate the molecular principles of brain wiring in mammals and how small changes can generate complex outcomes. Neurons in the mammalian brain must be precisely wired together for the brain to function correctly. The project aims to identify the molecular and cellular rules governing commissural wiring in the mammalian cortex to determine how the largest fibre tract in the human brain, the corpus callosum, evolved. This may have involved modifications in mechanisms affecting axon guidance that differ between placentals and marsupials. The project investigates the regulatory gene networks determining commissural neuron fate, the regulation of axon guidance components, and the influence of surrounding brain tissue on the development of commissural connections.