I-Corps: Functional Microscale Medical Adhesives

在这个项目中，该团队将使用双光子聚合和微模塑来制备功能性微型医用粘合剂，以克服与液体伤口密封剂和其他传统伤口封闭材料相关的并发症。在最近的工作中，该团队使用间接快速成型方法(涉及双光子聚合和微成型)，从基于丙烯酸酯的聚合物中创造出了双管齐下、八管齐下、十管齐下和十管齐下的聚合物。在目前的工作中，他们正在通过用孟加拉玫瑰修饰组织倒钩材料来创造“功能性组织倒钩”。孟加拉玫瑰是一种生物相容材料，在绿光激活后，已被用于促进组织结合和伤口愈合。I-Corps项目的资源将支持含有光活化组织粘合剂的聚合物组织倒钩的双光子聚合/微成型，以及使用生物、机械和功能(例如，身体猪皮肤连接)研究来表征功能性组织倒钩。伤口部位炎症和疤痕形成是与传统伤口闭合材料相关的并发症。一种结合双光子聚合和微成型的间接快速成型方法将用于从孟加拉玫瑰修饰的聚合物中高通量复制功能组织倒钩。这些倒钩必须表现出生物兼容性和适当的机械性能才能临床使用。含有光活化组织粘合剂的功能性组织倒钩将使用双光子聚合和微模塑廉价地生产出来，供医生在从初级保健医生办公室到手术室的各种临床环境中使用。如果成功商业化，这项技术有可能以积极的方式显著影响医疗保健行业治疗大范围伤口的方式。

In this project, the team will use two photon polymerization and micromolding in order to prepare functional microscale medical adhesives that overcome complications associated with liquid wound sealants and other conventional wound closure materials. In recent work, the team created two-pronged, eight-pronged, ten-pronged, and sixteen-pronged out of an acrylate-based polymer using an indirect rapid prototyping approach that involved two photon polymerization and micromolding. In current work, they are creating "functional tissue barbs" by modifying tissue barb materials with rose bengal. Rose bengal is a biocompatible material that has been used to facilitate tissue bonding and wound sealing after photoactivation by green light. Resources from the I-Corps project will support two photon polymerization/micromolding of polymeric tissue barbs containing photoactivated tissue bonding agents as well as characterization of functional tissue barbs using biological, mechanical, and functional (e.g., cadaveric swine skin joining) studies. Wound site inflammation and scar formation are complications that are associated with conventional wound closure materials. An indirect rapid prototyping approach that involves a combination of two photon polymerization and micromolding will be used for high-throughput replication of functional tissue barbs from rose bengal-modified polymers. These barbs must exhibit biocompatibility and appropriate mechanical properties for clinical use. Functional tissue barbs containing photoactivated tissue bonding agents will be inexpensively produced using two photon polymerization and micromolding for use by medical practitioners in a variety of clinical settings, from the primary care physician's office to the surgical suite. If successfully commercialized, this technology has the potential to significantly impact, in a positive way, the way the health care industry treats a wide area of wounds.