MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Research and Education

俄亥俄大学的Tadeusz Malinski教授及其同事Eric Masson、Stephen Bergmeier、Michael Jensen和Jennifer Hines将获得由化学研究仪器和设施(CRIF)计划共同资助的主要研究仪器计划颁发的这一奖项，他们将获得一台500 MHz核磁共振波谱仪(11.7特斯拉磁铁，内径54毫米，带主动屏蔽)。新的光谱仪将具有梯度匀场、4个射频通道、一个可变温度单元和三个探测器：一个用于观察1H同时去耦合13C和15N核的反三重共振微探测器和一个多核宽带荧光观测SmartProbe。该项目旨在加强各级的研究和教育，特别是在下列领域：(A)从天然产物和合成制剂中研究高度复杂的大分子；(B)合成具有药用价值的天然和非天然产物；(C)利用超分子化学研究大环葫芦家族的识别特性和应用；(D)鉴定在较低场强下收集的光谱中具有大量重叠芳香质子的高取代多吡啶金属络合物；(E)利用顺磁核磁共振技术；(F)开发以RNA为靶标的配体；和(G)一氧化氮(NO)信号通路核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该工具将是教学和研究的一个组成部分，并将影响大量学生，包括一些来自阿巴拉契亚俄亥俄州地区的学生以及工业伙伴关系。合作将使来自里奥格兰德大学和肖尼州立大学的学生接触到核磁共振仪器的科学能力。

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor Tadeusz Malinski from Ohio University and colleagues Eric Masson, Stephen Bergmeier, Michael Jensen and Jennifer Hines will acquire a 500 MHz NMR spectrometer (11.7 Tesla magnet, 54 mm bore, with active shielding.) The new spectrometer would have gradient shimming, 4-radiofrequency channel, a variable temperature unit, and three probes: an inverse triple resonance microprobe for the observation of 1H while decoupling 13C and 15N nuclei and a multinuclear broadband Fluorine Observe SmartProbe. The project is aimed at enhancing research and education at all levels, especially in areas such as (a) study of highly complex macromolecules from natural products and from synthetic preparations; (b) synthesis of medicinally relevant natural and unnatural products; (c) study of recognition properties and applications of the Cucurbituril family of macrocycles using supramolecular chemistry; (d) identification of highly substituted polypyridine-metal complexes that have a large number of overlapping aromatic protons in spectra collected at lower field strength; (e) use of paramagnetic NMR techniques; (f) development of RNA-targeted ligands; and (g) nitric oxide (NO) signaling pathways.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research and will impact a large number of students including some from the Appalachian Ohio region and also industrial partnerships. Collaborations will expose students from the University of Rio Grande and Shawnee State to the scientific capabilities of NMR instrumentation.