MRI: Acquisition of a 500 MHz NMR for Faculty Research and Undergraduate Training at Western Washington University

在主要研究仪器计划（MRI）和化学研究仪器计划（CRIF）的支持下，西华盛顿大学将获得一台500 MHz核磁共振光谱仪，配备三通道氮冷却探头。光谱仪将允许在生物化学、无机和合成有机化学以及材料科学等领域进行研究。这项研究将影响生物和环境领域，如DNA稳定性和结构、血液替代品、燃料电池和二氧化碳减排。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。该仪器将成为西华盛顿大学本科生和硕士生进行教学和研究的一个组成部分。这些设备和相关培训将免费提供给包括西雅图大学和西雅图地区其他机构在内的地区机构的教职员工和学生。该奖项旨在加强研究，特别是在以下领域的研究：(a)绒毛蛋白/超绒毛蛋白家族的细胞骨架调节蛋白的结构/动力学和功能；(b)利用富土金属作为催化剂，将二氧化碳分子还原为可用的C1源；(c) permutein肌红蛋白和单链血红蛋白作为潜在的合成血液替代品的结构/动力学研究；(d)与环境和生物有关的天然产物的对映选择性合成；(e)与多肽底物络合的分选酶的结构/动力学；(f)探索导电生物材料的设计；(g)聚合物定向合成用于燃料电池催化的多金属纳米颗粒。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Western Washington University will acquire a 500 MHz NMR spectrometer with a triple channel nitrogen-cooled probe. The spectrometer will allow research in the areas of biochemistry, inorganic and synthetic organic chemistry, and the material sciences among others. The research will impact areas of biological and environmental interest such DNA stability and structure, blood substitutes, fuel cells and carbon dioxide mitigation. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument will be an integral part of teaching as well as research performed by undergraduate students and masters degree students at Western Washington University. The equipment and associated training will be available free-of-charge to faculty and students at regional institutions,including Seattle University and others from the Seattle area. The award is aimed at enhancing research especially in areas such as studying (a) structure/dynamics and function of the cytoskeleton modulating proteins of the villin/supervillin family; (b) reduction of the carbon dioxide molecule into useable C1 sources utilizing earth abundant metals as catalysts; (c) structure/dynamics investigation of permutein myoglobins and single-strand hemoglobins as potential synthetic blood substitutes; (d) enantioselective synthesis of environmentally- and biologically-relevant natural products; (e) structure/dynamics of sortase enzymes complexed with their polypeptide substrates; (f) probing the design of conductive biomaterials; and (g) polymer-directed synthesis of multimetallic nanoparticles for fuel cell catalysis.