Standardized Performance Testing of Multispectral Reflectance Oximetry Imaging (MROI) in Emerging Device Platforms

PI将开发表征微创诊断医疗器械的先进方法。该研究将促进用于早期疾病检测和图像引导手术的新型生物光子技术的开发和标准化性能测试。将开发用于近红外光谱系统（NIRS）性能测试的3D打印仿生模型，PI将通过基于模型的测量研究近红外（IR）荧光（NIRF）图像质量，以探索开发可用于验证NIRF成像系统的标准的基础。用于非侵入性荧光分子成像（FMI）的新型仿生体模的开发将阐明影响3D打印体模有效性的最佳制造方法。

The PI will develop advanced methods for characterizing minimally-invasive diagnostic medical devices. The research will facilitate the development and standardized performance testing of novel biophotonic technologies for early disease detection and image-guided surgery. 3D-printed biomimetic phantoms for the performance testing of near-infrared spectroscopy systems (NIRS) will be developed and the PI will investigate near-infra-red (IR) fluorescence (NIRF) image quality through phantom-based measurements to explore the basis for developing standards that can be used to validate NIRF imaging systems. The development of novel biomimetic phantoms for noninvasive fluorescence molecular imaging (FMI) will elucidate optimal fabrication approaches that influence the effectiveness of 3D-printed phantoms.