MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Support Research Projects from C-H Bond Oxidation to Engineered Molecular Materials

该奖项由主要研究仪器项目和化学研究仪器项目支持。堪萨斯州立大学的杜伊·华教授及其同事Daniel Higgins、Stefan Bossmann、Jun Li和Emily McLaurin获得了一台具有溶液和固态功能的混合400 MHz核磁共振光谱仪。这种光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及允许研究与生物相关的物种。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。该工具积极影响了堪萨斯州的研究人员，特别是那些主要是该地区的本科生机构的研究人员。该团队拥有网络基础设施，用户可以远程接收、操纵和分析光谱。授予这种混合核磁共振光谱仪的目的是加强各级的研究和教育。特别是对烷烃的催化不对称C-H键氧化、寡肽和荧光染料的合成等领域的影响更大。该光谱仪用于表征多相催化剂上羟醛缩合的单分子荧光，并利用多重方法快速富含蛋白酶。此外，它还有助于微波辅助离子液体刻蚀胶体半导体纳米晶，以及用于研究非均相纳米结构的染料衍生物的合成。该仪器还可用于研究A类和B类染料脱色过氧化物酶、木质素降解机理和应用，以及硫族/卤素或氢键的超分子化学。最后，该仪器还被用于识别生物启发的金属有机骨架(MOF)，用于纳米其他方面的应用，以及用于烯烃合成催化剂的机械研究。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Duy Hua from Kansas State University and colleagues Daniel Higgins, Stefan Bossmann, Jun Li and Emily McLaurin have acquired a hybrid 400 MHz NMR spectrometer with solution and solid-state capabilities. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The instrument positively impacts researchers across Kansas, particularly those primarily undergraduate institutions in the region. The team has cyber-infrastructure available to users to receive, manipulate and analyze the spectra remotely. The award of this hybrid NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts areas such as catalytic asymmetric C-H bond oxidation of alkanes and the synthesis of oligopeptides and fluorescent dyes. The spectrometer is used tocharacterize single molecule fluorescence of aldol condensation on heterogeneous catalysts and rapidly profilling protease using a multiplex method. In addition, it aids microwave-assisted ionic liquid etching of colloidal semiconductor nanocrystals and the synthesis of dye derivatives for studies of heterogeneous nanostructures. The instrument also serves researchers studyingf A- and B-class dye-decolorizing peroxidases lignin degradation mechanism and applications and supramolecular chemistry of chalcogen/halogen or hydrogen bonding. Finally, the instrumentation is also used to identify bio-inspired metal-organic-framework (MOFs) for applications in nanotheranostics, and for mechanistic investigations of olefin methathesis catalysts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.