Defining the membrane protein cargo transported by Retromer

该项目旨在定义Retromer的作用，这是一种蛋白质机器，可以指导细胞内蛋白质的组织和运动。蛋白质的功能取决于它们如何在细胞内的不同区域或隔室中穿行。一个称为核内体的细胞内腔室是这个动态过程的中心。生物分子通过内体细胞器的细胞内运输对正常的细胞过程如信号传导和发育至关重要。内体运输发生在由Retromer形成的膜结构域和膜泡载体内。该项目旨在定义由细胞内形成的不同逆转录复合物分类的跨膜蛋白，以及对其正确运输和定位至关重要的分类信号。

This project aims to define the role of Retromer, a protein machine that directs the organisation and movement of proteins within the cell. The function of proteins is dependent on how they travel through the various regions or compartments within the cell. One intracellular compartment, termed endosomes, is central to this dynamic process. Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling and development. Endosomal transport occurs within membrane domains and membrane vesicular carriers formed by Retromer. This project aims to define the transmembrane proteins sorted by the distinct retromer complexes that form within the cell and the sorting signals essential for their correct trafficking and localisation.