The 5th Stevens Conference on Bacteria-Material Interactions

该项目支持一个名为史蒂文斯细菌-物质相互作用会议的研究会议。这个为期两天的会议将于2019年6月在新泽西州霍博肯史蒂文斯理工学院的校园举行，离纽约市很近。2019年的会议是自2011年开始的系列会议中的第五次会议，该系列会议被认为是推动对细菌如何与人造表面相互作用的科学理解的极限的关键国家和国际场所。细菌-物质相互作用是一个重要的科学课题，因为人造生物医学设备（如髋关节或膝关节植入物）的细菌定植会对患者的预后产生破坏性影响。这种感染可导致长期痛苦的住院，最终导致功能受损、慢性疾病或死亡。该项目旨在帮助研究生、博士后研究员和早期职业教师参加会议，并在这一重要的新兴领域发展他们的专业知识和职业生涯。技术摘要：了解细菌如何与生物材料表面相互作用的基础科学，以及如何修改这些表面以抵抗定植，是生物材料科学与工程中新出现的子领域的核心，即抗感染生物材料。虽然创造抗细菌定植的防污表面的想法已经知道了几十年，但防污表面在许多关键的临床应用中并不有用，因为它们抵抗细菌定植的能力也阻止了与愈合相关的理想组织相互作用。因此，科学挑战集中在创造具有差异相互作用的表面，同时促进有利的组织-细胞相互作用，同时抑制细菌相互作用。为了深入探讨这一主题，第五届史蒂文斯会议的重点是科学基础，解决：(i)抗菌剂和抗菌作用；（ii）感染模型；（iii）细菌对表面的反应；（四）表面改性。会议的特色是邀请来自世界各地的公认的专题专家进行15次演讲。重要的是，会议还涉及高度专业的临床医生的观点，他们可以帮助使基础科学进步与关键的社会需求保持一致。该项目提供部分资金支持，使研究生、博士后研究员和早期职业教师能够参加会议。因此，这些年轻的科学家和工程师有机会展示他们自己的研究成果，与该领域的国际公认专家建立联系并向他们学习，以及发展他们的职业生涯，以帮助影响未来这一重要的新兴领域。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Nontechnical abstractThis project supports a research conference called the Stevens Conference on Bacteria-Material Interactions. This two-day Conference will be held in June 2019 on the campus of the Stevens Institute of Technology in Hoboken, New Jersey, very close to New York City. The 2019 Conference is the 5th in a series of Conferences that started in 2011, and this series is recognized as a key national and international venue for pushing the limits of scientific understanding about how bacteria interact with man-made surfaces. Bacterial-material interactions is an important scientific subject because of the devastating impact that bacterial colonization of man-made biomedical devices, such as hip or knee implants, can have on patient outcomes. Such infection can lead to long and painful hospital stays that can culminate in compromised function, chronic disease, or death. This project is helping graduate research students, post-doctoral research fellows, and early-career Faculty members to attend the conference and develop their expertise and professional careers in this important emerging field.Technical abstractUnderstanding the fundamental science underlying how bacteria interact with biomaterials surfaces and how those surfaces can be modified to resist colonization is at the heart of an emerging new sub-field within Biomaterials Science and Engineering, namely, infection-resisting biomaterials. While the idea of creating antifouling surfaces that resist bacterial colonization has been known for decades, antifouling surfaces are not useful in many key clinical applications, because their ability to resist bacterial colonization also prevents the desirable tissue interactions associated with healing. The scientific challenge thus focuses on creating surfaces that are differentially interactive and can simultaneously promote favorable tissue-cell interactions while also inhibiting bacterial interactions. To deeply explore this subject, the 5th Stevens Conference is focused on the scientific fundamentals addressing: (i) antimicrobials and antimicrobial action; (ii) infection models; (iii) bacterial response to a surface; and (iv) surface modification. The Conference features fifteen invited lectures by recognized topical experts from around the world. Significantly, the Conference also involves the perspectives of highly expert clinicians who can help keep fundamental scientific advances aligned with critical societal needs. This project is providing partial financial support that enables graduate research students, post-doctoral research fellows, and early-career Faculty members to attend the Conference. These young scientists and engineers consequently have the opportunity to present their own research findings, network with and learn from internationally recognized experts in the field, as well as develop their professional careers to help impact this important emerging field in the future.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.