MRI: Acquisition of a Liquid Chromatograph-High Resolution Mass Spectrometer to Characterize Organic Molecules of Environmental and Health Significance

天然有机分子和合成有机分子在生态系统和人类健康中发挥着多方面的作用。对这些有机分子的全面表征有助于促进我们对影响社会的各种环境和健康挑战的科学理解。该项目支持在锡拉丘兹大学(SU)购买一台最先进的高效液相色谱-高分辨率质谱仪(LC-HRMS)。该仪器将加强对不同样品中有机分子测量的研究和培训，并使纽约市中心的SU调查人员和研究人员能够解决环境与健康界面上的多学科研究问题。该仪器还将加强苏州大学的课程和研究培训计划，并扩大来自代表性不足群体的学生参与科学调查，以促进多样性和包容性，参与南加州大学的合作研究和创造性工作。获得液态色谱仪-高分辨率质谱仪(LC-HRMS)将为锡拉丘兹大学(SU)带来下一代分析工具，以支持从污染物筛选和分子指纹到结构和定量蛋白质组学等广泛的质谱学应用。该仪器将填补苏州大学在有机分析设施方面的一个关键空白，并加快许多正在进行和计划中的国家优先领域研究项目的步伐，如水质和处理、生物地球化学、室内环境质量、化学生物学和生物灵感材料。这一工具将为苏州大学的教职员工和学生提供新的机会，以开发新的筛选和发现工作流程，并与来自纽约市中心和其他地区的跨学科和多机构的研究人员进行新的跨学科合作。该仪器还将通过新的主动学习课程模块和研究培训计划，让SU学生接触尖端的质谱学方法，并为他们配备进一步教育所需的分析技能和科学思维。将该仪器作为共享用户设施运营的长期愿景是，通过向SU和地区社区提供新的分析能力和技术专长，追求前沿研究并加强SU的核心教育使命。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

Naturally occurring and synthetic organic molecules play multifaceted roles in the ecosystem and human health. Comprehensive characterization of these organic molecules help advance our scientific understanding of various environmental and health challenges that impact society. This project supports the acquisition of a state-of-the-art liquid chromatograph-high resolution mass spectrometer (LC-HRMS) at Syracuse University (SU). This instrument will enhance research and training on the measurement of organic molecules in diverse samples and enable SU investigators and researchers in central New York to tackle multidisciplinary research questions at the interface of environment and health. This instrument will also strengthen SU’s curriculum and research training programs and broaden participation of students from underrepresented groups in scientific inquiries to foster diversity and inclusion in collaborative research and creative work at SU.Acquisition of a liquid chromatograph-high resolution mass spectrometer (LC-HRMS) will bring to Syracuse University (SU) a next-generation analytical tool to support a broad array of mass spectrometry applications ranging from contaminant screening and molecular fingerprinting to structural and quantitative proteomics. This instrument will fill a crucial gap in organic analytical facilities at SU and accelerate the pace of many ongoing and planned research projects in priority areas of national interest, such as water quality and treatment, biogeochemistry, indoor environmental quality, chemical biology, and bioinspired materials. This instrument will present new opportunities for SU faculty and students to develop novel screening and discovery workflows and to engage in new interdisciplinary collaborations with researchers spanning multiple disciplines and multiple institutions from central New York and beyond. This instrument will also expose SU students to cutting-edge mass spectrometry methods via new active-learning course modules and research training programs and equip them with analytical skills and scientific thinking needed to further their education. The long-term vision for operating this instrument as a shared user facility is to pursue leading-edge research and enhance SU’s core education mission by providing new analytical capabilities and technical expertise to SU and regional communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.