Erleichterte Virus Replikation während einer Virusinfektion: Relevanz für Virus Persistenz und Impfung (C06)

C6项目使用强制病毒复制的免疫学概念来增强针对慢性病毒的疫苗应答。PI Lang显示CD 169+巨噬细胞复制病毒以允许抗原呈递和T细胞应答的有效引发。他定义了几种与强制病毒复制机制密切相关的分子。分子靶标现在将被现有抗体阻断或诱导，以在针对慢性感染的治疗性疫苗接种期间改善强制病毒复制。该新策略将在三种动物模型中进行测试，即VSV-HIV感染、慢性FV感染和人源化BLT小鼠的HIV感染。

Project C6 uses the immunological concept of enforced viral replication to enhance vaccine responses against chronic viruses. The PI Lang showed that CD169+ macrophages replicate virus to allow antigen presentation and efficient priming of T cell responses. He defined several molecules that are critically involved in the mechanism of enforced virus replication. The molecular targets will now be blocked or induced with existing antibodies to improve enforced viral replication during therapeutic vaccination against chronic infections. The novel strategy will be tested in three animal models, VSV-HIV infection, chronic FV infection and HIV infection of humanized BLT mice.