MRI: Acquisition of a 500 MHz NMR for Expanding Research and Training in the Wichita Region

该奖项由化学部的主要研究仪器和化学研究仪器计划共同支持。威奇托州立大学正在购买一台配备液氮冷却探头的500 MHz核磁共振（NMR）光谱仪，以支持James班恩教授和同事Moriah R.作者：William C. Groutas，Katie Mitchell-Koch，and Haifan Wu.该仪器促进了药物设计，癌症治疗，纳米材料和聚合物化学领域的研究。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。相对于标准NMR探针，氮气冷却探针提供了灵敏度的显著增加。该仪器增强了威奇托州立大学和包括29所农村学院和大学以及当地化学、生物技术和航空工业在内的更广泛地区的许多部门的各级学生的教育、研究和教学努力。500 MHz NMR光谱仪的获奖旨在加强各级的研究和教育，特别是在结构、蛋白质，肽和大分子结构的动力学和相互作用，并推进氟和磷化学位移的理论理解。 该仪器使研究集中于细菌孔形成蛋白的结构-功能、参与肌动蛋白结合的构象动力学和帕拉丁的IG结构域对细胞运动的调节，以及设计新的限制性肽以靶向蛋白质-蛋白质界面。 它还有助于病毒丝氨酸和半胱氨酸蛋白酶的新型螺环大环抑制剂的结构导向设计以及先进聚合物材料的设计和合成。 其他研究包括计算指导的磷核磁共振谱和生物分子的氟核磁共振研究的解释，以及新型氰尿酸配体的金属络合物的结构和电子性质。该奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs in the Division of Chemistry. Wichita State University is acquiring a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a liquid nitrogen cooled probe to support the research of Professor James Bann and colleagues Moriah R. Beck, William C. Groutas, Katie Mitchell-Koch, and Haifan Wu. This instrument facilitates research in the areas of drug design, cancer therapeutics, nanomaterials, and polymer chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The nitrogen-cooled probe provides a significant increase in sensitivity relative to standard NMR probes. This instrument enhances the educational, research, and teaching efforts of students at all levels in many departments at Wichita State University and in the broader region including 29 rural colleges and universities as well as local chemical, biotech, and aviation industries.The award of the 500 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as structure, dynamics and interactions of proteins, peptides, and macromolecular architectures, and advancing a theoretical understanding of fluorine and phosphorous chemical shifts. This instrument enables research focused on the structure-function of bacterial pore forming proteins, conformational dynamics involved in actin binding and regulation of cellular motility by Ig domains of palladin, and designing novel constrained peptides to target protein-protein interfaces. It also assists in the structure-guided design of a novel class of spiro macrocyclic inhibitors of viral serine and cysteine proteases and the design and synthesis of advanced polymeric materials. Other investigations include the computationally guided interpretation of phosphorus NMR spectra and fluorine NMR studies of biomolecules, and the structure and electronic properties of metal complexes of novel cyanoscorpionate ligands.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.