Host cell targets of bacterial virulence effectors

本提案中描述的研究将有助于更好地理解宿主-病原体相互作用的细胞生物学。我们处于一个独特的位置来分析细菌毒力决定因素和宿主细胞蛋白之间的蛋白质/蛋白质相互作用的重要性，使用一系列细胞生物学技术来解决宿主-病原体相互作用的基本分子基础。此外，我们将构建一个新的遗传工具，以确定新的细菌毒力决定因素。我们预计，对促成宿主-病原体相互作用的因素的更多了解将为动物，植物和人类的细菌病原体对宿主细胞过程的颠覆提供新的见解。

The research described in this proposal will result in a better understanding of the cell biology of host-pathogen interactions. We are in a unique position to analyze the importance of protein/protein interactions between bacterial virulence determinants and host cell proteins using a range of cell biology techniques to address the fundamental, molecular basis of the host-pathogen interaction. In addition we will construct a new genetic tool to identify novel bacterial virulence determinants. We anticipate that a greater knowledge of the factors that contribute to the host-pathogen interaction will provide new insights into the subversion of host cell processes by bacterial pathogens of animals, plants and humans.