Function and regulation of the Schlafen gene family: novel regulators of blood cell proliferation and function.

拟议研究的直接成果将是对Schlafen基因参与的重要细胞和生物过程的基础知识和理解。特别是，Schlafen基因可能在炎症反应和血细胞生长中发挥作用。这些过程显然与一系列主要的人类（和动物）疾病有关，包括传染病、自身免疫疾病和白血病，因此长期结果可能是改善对这种疾病的治疗。

The immediate outcomes of the proposed research will be in fundamental knowledge and understanding of important cellular and biological processes in which the Schlafen genes are involved. In particular, Schlafen genes are likely to play a role in inflammatory responses and in blood cell growth. These process clearly have relevance to a range of major human (and animal) diseases including infectious disease, auto-immune disease and leukaemia, and thus a long-term outcome may be improved treatments for such disease.