Development of Perfluoroalkylation Based on the Ate Complex Chemistry

研究了Me_2Zn与LiCl反应生成稳定的全氟烷基锌试剂的方法。虽然全氟烷基锂和Gregnard试剂由于容易的α-或β-金属氟化物（M-F）消除而不稳定，但是由此获得的全氟烷基锌物种是稳定的并且可以在室温下使用。理论研究已经揭示了稳定性的起源，与锂试剂相比。该系统也适用于生成全氟苯基锌物质。应用于亲核全氟烷基化和全氟苯基化反应。

The generation method of stable perfluoroalkylzinc reagents from perfluoroalkyl iodide using the combination of Me2Zn and LiCl has been developed. Although perfluoroalkyllithium and Gregnard reagents are unstable due to facile α- or β-metal fluoride (M-F) elimination, the perfluoroalkylzinc species thus obtained is stable and can be utilized at room temperature. Theoretical investigations have revealed the origin of the stability, compared to that of lithium reagents. This system is also applicable for the generation of perfluorophenylzinc species. The application to the nucleophilic perfluoroalkylation and perfluorophenylation has been demonstrated.