Development of bioglass coated titanium implant

为了探讨混杂材料(Ti6Al4V生物玻璃涂层)在临床上应用于骨内种植体的可能性，用日本猴进行了两个实验：(1)比较了两种种植体的初始骨愈合情况。分别采用攻丝和非攻牙两种方法植入双侧下颌骨无牙区。两种种植体均覆盖全厚粘膜骨膜瓣，愈合时间为3个月。无论采用何种植入方式，生物玻璃涂层种植体均表现出良好的骨性愈合，直接与骨结合，而未涂覆生物玻璃涂层的对照组种植体骨与种植体之间可见大量纤维结缔组织。(2)将生物玻璃种植体以非攻丝方式植入下颌骨，并通过上层建筑施加功能应力。术后3个月、6个月、9个月取材。种植体-骨界面沿螺纹式种植体轮廓的大部分区域均有明显的方向性。

To examine a possibility of clinical use of the hybrid material (Ti6Al4V with Bioglass coating) for endosseous dental implant, two experiments were performed using Japanese monkeys.(1) Initial bone healing was compared histologically between two implants. There were inserted into edentulous areas of both sides of the mandible, one by tapping and the other by non-tapping methods. Both implants were covered with a muco-periosteal flap of full thickness and allowed to heal for 3 months. All bioglass-coated implants, which ever the insertion method was, showed good healing with direct bone apposition, where as the controls without bioglass coating revealed various amonts of fibrousconnective tissue between bone and implant.(2) Bioglass implants were inserted into the mandible by non-tapping method and loaded with functional stress by means of the superstructure. After 3, 6 and 9 months of function, histological specimens were prepare. Directory bone-implant interface was obviously achived in most regions along the outline of screw-saped implants.