On-line measurement and processing system of cognitive event-related potentials for testing abnormal verbal behavior

1.对现有的事件相关电位（ERPs）测量和处理系统进行了扩展，增加了DMA数据采集模块，从而完成了一个能够同时控制言语任务负荷、测量ERPs和反应时的在线测试系统.该系统用于正常人以及患有言语障碍的精神病患者，特别是精神分裂症患者的初步临床实验，以检查在工作算法和程序中的问题，这些算法和程序用于产生随机序列，编辑和归档言语/非言语刺激数据，用双耳呈现加载言语任务，ERP处理，RT测量，图形显示和归档平均ERP，绘制ERP，提取特征参数并归档，RT统计处理，打印ERP/RT数据，ERP和RT测量数据离线备份和归档.为了检验本系统作为测试异常言语行为的在线站，进行了一些试验，将处理后的文件传输到中央计算机，用于检查正常人和药物治疗/非药物治疗患者的区分程序。建立了双侧听觉信息加工的神经突触模型以及脑电和事件相关电位（ERPs）的神经突触模型，以分析脑内时间信息加工与头脑活动如事件相关电位（ERPs）、节律性脑电（rhythmic EEG）等的相关性。

1. An extention of the present system for measurement and processing of event-related potentials (ERPs) was done by adding a DMA data acquisition module in order to complete an on-line testing system with an ability of simultaneous control of verbal task loading and measurements of ERPs as well as reaction times (RTs).2. The system was used in preliminary clinical experiments on mormals as well as psychiatric patients with verbal disorders, especially schizophrenics to check problems in working the algorhisms and programs for generation of randome sequences, editing and filing of verbal/nonverbal stimulus data, loading of verbal tasks with binaural presentation, ERP processing, RT measurement, graphic displaying and filing of averaged ERPs, plotting RRPs as well as extracting and filing feature parameters, statistical processing of RTs, printing ERP/RT data, and off-line backup for measurements and filing of ERPs and RTs.3. Some trials were done on tranferring the processed files to a central computer for checking the discrimination program on normals and medicated/nonmedicated patients in order to examine the present system as an on-line station for testing abnormal verbal behavior.4. A neuro-synaptic model of bilateral auditory information processing was composed as well as a neuro-synaptic model of cerebral EEGs and ERPs in order to analyze the correlation between the temporal information processing within a brain and the scalp brain activities such as ERPs, rhythmic EEGs, etc..