Developmental Research for Computer Diagnostic System of Disorders of Motor Function by Using the 2-Dimensional Manual Control System

近年来，帕金森综合征、小脑性共济失调、肌肉萎缩症、中风等顽固性运动功能障碍的医学治疗已成为人们普遍关注的问题。为了早期有效地诊断这些疾病，必须发展一种新的人体运动功能检测方法。我们研究的主要目的是利用二维手动控制系统开发一种新的运动功能检查系统，以便我们可以定量评估药物治疗或康复，并利用个人计算机系统进行自动诊断。首先，在一维手动控制系统中进行的一些实验显示了帕金森病和小脑共济失调这两种中枢神经系统疾病对自主运动预测控制功能的影响。这表明，学习过程、被操纵变量速率的功率谱和相干函数可以作为诊断疾病的有用参数。此外，我们还研究了人工控制系统中人类对参考输入的适应性，并表明所提出的模型可以实现具有延迟的线性系统的输出调节，可以近似于通常模型难以解释的频率响应。通过在被控对象的水平极性或垂直极性反转的二维手动控制系统中进行的实验，我们已经表明，相对于被控对象的反向，人类操作员的控制特性具有各向异性。本研究提出的系统能够客观、定量地检测其他神经学检测方法所不能检测到的视、身感觉整合功能，并通过引入计算机自动诊断算法，提供了一种更加实用有效的检测方法。少

Recently, medical treatment for intractable diseases attended with disorders of the motor function such as Parkinson syndrome, cerebellar ataxia, muscular dystrophy, apoplexy, and so on has become of general interest. In order to diagnose these diseases efficiently in an early stage, a new method of examining the human motor function should be developed. The major purpose of our researches is to develop a new examination system of the motor function using the 2-dimensional manual control system so that we can quantitatively evaluate medical therapy or rehabilitation and make an automatic diagnosis by using a personal computer system.First, several experiments in the 1-dimensional manual control system have shown the effects of two central nervous system diseases, i.e. Parkinsonism and cerebellar ataxia, on the predictive control function of voluntary movements. This has indicated that the learning process, the power spectrum of rate of the manipulated variable and the coherency functio … More n can become useful parameters to make a diagnosis for discriminating the diseases.Moreover, we have studied human adaptability to the reference input in the manual control system and shown that the proposed model realizing output regulation for a linear system with delay can approximate the frequency response which cannot be explained easily by usual models.Using the experiments in the 2-dimensional manual control system in which either the horizontal polarity or the vertical one of the controlled object is reversed, we have shown that the control characteristics of the human operator have anisotropy with respect to the reverse direction of the controlled object.The system proposed in this study can make an objective and quantitative examination of the integration function of visual and somatic sensations which cannot be carried out by any other neurological tests and could give a more practical and effective examination method by introducing some computer algorithms for an automatic diagnosis. Less