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Identification of functionally important autophosphorylation site(s) on ataxia telangiectasia and Rad 3 - related (ATR) protein kinase.

Identification of functionally important autophosphorylation site(s) on ataxia telangiectasia and Rad 3 - related (ATR) protein kinase.
共济失调毛细血管扩张症和 Rad 3 相关 (ATR) 蛋白激酶上功能重要的自磷酸化位点的鉴定。
批准号:
DP0666572
负责人:
Prof Martin Lavin
金额:
$18.34万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2006
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2006-01-01 至 2009-09-30

项目摘要

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中文摘要
翻译
我们必须保持遗传物质的完整性,以便将其代代相传,并将个人患癌症和其他病理疾病的风险降至最低。有多种蛋白质参与保护我们的DNA,包括几种酶,它们检测DNA损伤并向一系列途径发出信号,这些途径涉及阻止细胞通过细胞周期,以便进行修复。该项目研究了其中一种酶的作用机制,这将有助于设计新的化合物来抗击疾病。
英文摘要
The integrity of our genetic material must be maintained so that it can be passed on from one generation to the next and also to minimize the risk of cancer and other pathologies in an individual. There are multiple proteins involved in protecting our DNA including several enzymes that detect and signal DNA damage to a series of pathways involved in halting the passage of cells through the cell cycle so that repair can occur. This project studies the mechanism of action of one of these enzymes which will be of benefit in designing new compounds to fight disease.
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Role of senataxin protein in meiotic recombination and sex chromosome inactivation
  • 批准号:
    DP130100389
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $25.36万
  • 财政年份:
    2013
  • 负责人:
    Prof Martin Lavin
  • 依托单位:
Research Fellowship
  • 批准号:
    nhmrc : 1020028
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $73.48万
  • 财政年份:
    2012
  • 负责人:
    Prof Martin Lavin
  • 依托单位:
Role of Senataxin in protecting against neurodegeneration
  • 批准号:
    nhmrc : 631407
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $35.99万
  • 财政年份:
    2010
  • 负责人:
    Prof Martin Lavin
  • 依托单位:
Characterisation of the novel mitochondrial protein (CABC1/ADCK3) and its role in protecting against oxidative stress
  • 批准号:
    DP1092466
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $20.85万
  • 财政年份:
    2010
  • 负责人:
    Prof Martin Lavin
  • 依托单位:
海外基金