Develoment of the Balloon cather System for intravasculat Surgery

球囊导管在血管造影诊断和治疗中的应用已被广泛接受。然而，需要更精密的系统来保证气囊导管的安全使用。列举了本研究所做的改进；不透光固化液；球囊导管栓塞所用的固化液应满足低粘度、放射性、适当的固化时间等要求。乙烯基单体与不透射线的化学物质的混合物满足了在真空下的大部分要求。然而，由于氧抑制自由基聚合，聚合不能在血管中进行。本研究利用葡萄糖氧化酶（GOD）开发了一种新的起始反应。神除去氧并将其转化为过氧化氢。生成的羟基过氧化氢被Fe（II）分解为羟基自由基。它可以引发残余聚合。通过改变GOD和/或Mohr's…More salt的浓度，可以很容易地缩短固化时间。不透射线封堵液；氰基丙烯酸酯是一种传统的使用脑动脉导管堵塞血管的方法。球囊有时会被氰基丙烯酸酯粘在血管上。球囊导管不能取出。新研制的不透射线堵漏液是乙炔乙基醇（EVL）、甲硝唑胺和二甲基亚砜的混合物。它没有氰基丙烯酸酯的大多数缺点。高频电源；该电源是专门为从导管中释放气球而开发的。它可以检测导管内导线是否短路或断线，甚至在有短路或断线的情况下也能释放出一个球体。双腔球囊导管是专门为使用第3节提到的混合物堵塞血管而开发的。我们认为，静脉导管。在这项研究中开发的系统是最复杂和安全的，可用于脑血管病变栓塞。少

The use of a balloon catheter in diagnostic and therapeutic angiography id now widely accepted. Howefer, More sophisticated system are desired to use the ballon catheter safely.The improvement done in this research are listed;1. Radiopaque solidigying liquid; Solidifying liquid used in balloon catheter embolization shouls satisfy the requeirements such as low viscosity, radiopague and appropriate solidifying time. The mexture of vinyl monomer and radiopaque chemicals satisties the most of the requirements under valum. However, the polymetization dose not proceed in the blood vessels because the oxygen inhibits the radical polymerization. In this study we developed a new initiation reaction using enzyme(glucose oxidase(GOD)). GOD removes oxygen and conberts it to hydroxy peroxide. The produced hydroxy peroxide is decomposed to a hydroxy radical by Fe(II). It can initiate resical polymerization. The solidifying time can be esaily abjested by changing the concetration of GOD and/or Mohr's … More salt.2. Radiopaque plugging luquid; Cynoacrylate is noventional used to plug blood vessels in cerebral arteriobvencous maiformation using a baslloon catheter. The balloon is sometimes stuck to a blood vessel by cyanoactylate. The balloon catheter can not be removed. Ht nuwly developed radiopaque plugging liquid is a mixture of ehtylene vinyl alcohon(EVL), metrizamide and dimethylsulfoxide. It is free from most of the disadvantages of cyanoacrylate.3. High frequency electrical current supply; The power supply has been especially developed to relase a balloon from catheter. It can detect the presence of shortciruiting ot broken wire of lead-in wires in the catheter and further can release a bal100n even the presence of then.4. The double lumen balloon catheter has been developed especially for plugging blood vessels using mexture mentined in section 3.We believe that the valloon catheter. systems developed in this research is most sophisticate and safely usable for embvolization of cerebrobascular lesions. Less