Application of Biocompatible Synthetic Materials for Tracheal Prosthesis

1.用狗、猪、兔和牛评价气管的力学性能，并与人的气管进行比较。用硅胶管和螺旋支架制作了无孔型人工气管。犬颈部气管的植入试验表明，这种类型的人工气管可引起吻合口的肉芽或裂开。我们得出结论，这种类型的人工气管对气管假体是不利的。在材料评价方面，我们用胶原蛋白处理的聚合物制备了样品。大鼠体内植入实验结果表明，该处理降低了材料的致瘤性，使材料具有较好的生物相容性。用胶原蛋白处理的聚丙烯网片在犬的气管上进行了窗形替换试验。术后缺损区内表面显示正常的气管黏膜上皮恢复良好。新型气管假体--…用经过胶原处理的卷曲聚丙烯网片制备了更多的SIS。这个网管是由缝合在网眼中的增强特氟龙纱线制成的。用该人工气管在犬颈部气管上进行了植入试验。它们的内表面覆盖着新生成的粘膜上皮。在某些情况下，由于假体的刺激，可观察到假体变形或吻合口处颗粒状组织的形成。这一结果表明，钢筋的结构还有待改进。对加固结构进行了改进。通过热处理将聚四氟乙烯纱线附着在网管的外表面上。犬气管置换试验结果良好。未见肉芽形成，也未见皱缩。人工气管上的气管上皮恢复良好。这些结果表明，该类型的气管足以用于临床使用。用生物可吸收聚丙交酯网片与自体骨膜复合，对兔气管进行环状置换试验。植入的骨膜周围可见软骨再生，提示该生物可吸收材料可用于人工气管。较少

1. Mechanical properties of the trachea were evaluated using dogs, pigs, rabbits and cows and were compared with human trachea.2. The non-porous type artificial tracheae using silicone tube with spiral stent were prepared. Implantation test at the cervical trachea on dogs revealed that this type of artificial trachea caused granulation or dehiscence at the anastomosis sites. We concluded that this type of artificial trachea is not good for tracheal prosthesis.3. As for the material evaluation, we prepared the sample made from polymers with collagen treatment. As the result of in vivo implantation test on rats revealed that this treatment reduces the tumorgenicity of materials which gives the materials better biocompatibility.4. The window shape replacement test on the dogs trachea was performed using collagen treated polypropylene mesh. After the operation the inner surface of the defect showed good recover of the normal mucosal epitherium of the trachea.5. New type of tracheal prosthe … More sis was prepares form the rolled polypropylene mesh which was treated collagen. This mesh tube was reinforced Teflon-yarns stitched in the meshes. Using this tracheal prosthesis, implantation test was performed on dogs cervical trachea. The inner surface of them were covered with new generated mucosal epitherium. In some cases deformations of the prosthesis or the granular tissue formation at the anastomosis sites due to the stimulation of the prosthesis were observed. This result indicated that the structure of the reinforcement must be improved.6. The reinforcement structure was improved. The Teflon-yarn was attached on the outer surface of the mesh-tube using the heat treatment. The replacement test on dogs trachea showed excellent results. Neither granulation formation nor constriction was observed. The recovery of the tracheal epitherium on artificial trachea was perfect. These results indicates that this type of trachea is sufficient for clinical use.7. Using composite of bioabsorbable poly lactide mesh and the auto periosteum, circular replacement test on the rabbits trachea was examined. Regeneration of cartilage was observed around the implanted periosteum, which may suggest the applicability of the bioabsorbable materials for artificial trachea. Less