STUDIES ON THE APPLICATION OF FOCUSED SHOCK WAVES TO THE CANCER TREATMENT

本文研究了水下冲击波的生物学效应及其在肿瘤治疗中应用的可能性，主要包括以下几个方面：1）水下冲击波对正常狗肾的作用（原位）。2)聚焦冲击波对小鼠后垫和犬膀胱内种植癌的影响。SW主要通过24片压电陶瓷元件进行基因评级。1）急性实验中，在与病灶区完全对应的肾R1区出现出血性病变。组织学观察表明，血管壁（主要是动脉）主要受损。出血病灶被瘢痕组织替代1个月。在超声B s观察下，在肾脏中观察到一个强回声区，全息干涉术揭示在水中，小气泡在聚焦区保留500毫秒。2）微爆炸产生的高能冲击波能抑制小鼠乳腺癌（MM 48）在小鼠后垫的生长，而低能冲击波（300 bar）不能抑制MM 48在小鼠后垫的生长。在V_2癌细胞移植的实验性膀胱肿瘤中，连续暴露于聚焦冲击波（1000 bar，2000-6000次/天，持续2-5天），可引起肿瘤明显坏死和缩小，结论：在本实验条件下，聚焦冲击波可引起肿瘤坏死和缩小。这些结果表明，一种新的模式，使用聚焦冲击波治疗癌症可能会打开和实体瘤，如果超声可视化，在未来的体外治疗。

The biological effect of underwater shock waves (SWs) has been studied and the possibility of its application to the cancer treatment also investigated through the following categories: 1)Effects of SW on the normal dog kidney (in situ). 2)Effects of focused shock waves on the implanted carcinoma in the mouse hind pad and the dog urinary bladder. The SWs were mainly gene rated by a 24-piece piezoceramic element. Targeting an object to the focus region was performed by an ultrasonic siagnostic system.1)In acute experiment the bleeding lesion was developed in the kidney R 1 exactly corresponding to the focus area. Histological observations suggested that the vessel wall(mainly of arteries) was primarily injured. The bleeding lesion was replaced by the scarring tissue for 1 month. Under ultrasonic b s observation a hyperechoic region was observed in the kidney.Holographic interferometry disclosed that small bubbles remained for 500msec in the focal region in water. These results suggested that cavitation damage may relate to the tissue injury.2)Growth of implanted mouse mammary carinoma (MM48) to mouse hind pad was suppressed after an application of high energy shock wave generated by micro explosion but not inhibited by a low energy shock wave ((300 bar). In experimental bladder tumor of implantation of V2 carinoma cells the successive a exposure to the focused shock waves (1000 bar, 2000-6000 shots/day for 2-5 days) induced marked tumor necrosis and decreased in tumor size.It is concluded that the focused shock waves induce tumor necrosis and decrease of tumor size under the present experimental conditions. These re sults suggest that a new modality of cancer treatment using focused shock waves may be opened and a solid tumor, if ultrasonically visualized, be extracorporeally treated in future.