600 MHz console for a solid-state NMR spectrometer

固态NMR提供了探测膜蛋白的可能性，无论其大小直接在膜环境中。我们使用这种方法将结构和动态数据与生化实验的信息联系起来。 例如，涉及实时检测膜内或膜处催化的反应。这些酶的生物化学稳定的中间体可以通过多维NMR实验表征。膜内的过程可以通过依赖于光的工具如笼或开关来控制。 感兴趣的蛋白质家族是次级转运蛋白、ABC转运蛋白、激酶和光受体。为了继续并扩大这些研究，需要更换切除的600 MHz核磁共振光谱仪内过时的核磁共振控制台，这就是本提案的目的。

Solid-state NMR offers the possibility to probe membrane proteins regardless of their size directly within the membrane context. We use this approach for linking structure and dynamic data with information from biochemical experiments. In involves for example real-time detection of reactions catalyzed within or at the membrane. Biochemically stabilized intermediates of these enzymes can be characterized by multidimensional NMR experiments. Processes within the membrane can be controlled by light-dependent tools such as cages or switches. Protein families of interest are secondary transporter, ABC transporter, kinases and photoreceptors. In order to continue and to expand these studies, an outdated NMR console within the excising 600 MHz NMR spectrometer needs to be replaced, which is the aim of this proposal.