The role of copper in the early ubiquitination pathway

该项目旨在探索铜在衰老和蛋白质周转中的作用。在生命的所有领域中，清除受损或多余的蛋白质是通过泛素标记来实现的。最近观察到，这一过程的最早步骤之一似乎是由铜驱动的。本项目旨在阐述铜调控这一重要的标记和蛋白质转换系统的精确生化机制。它提出表征的结构和功能的一种新发现的铜依赖形式的细胞酶可能参与放大泛素标记的蛋白质分解。铜在生活的各个领域都是必不可少的。确定铜作为蛋白质清除的主要调节因子对于理解这一基本生物机制非常重要。

This project aims to explore the role of copper in ageing and protein turnover. The removal of damaged or excess proteins is achieved by ubiquitin-tagging in all kingdoms of life. It has recently been observed that one of the earliest steps of this process appears to be driven by copper. This project aims to elaborate the precise biochemical mechanisms by which copper regulates this important tagging and protein turnover system. It proposes to characterise the structure and function of a newly identified copper-dependent form of cell enzyme which could be involved in amplifying ubiquitin-tagged protein breakdown. Copper is essential for life in all domains. Identifying copper as a major regulator in protein clearance is important in understanding this fundamental biological machinery.