Development of evaluation and diagnostic method on integration and its disorders of mental and language functions by analysis of synchronous oscillations in brain

我们的目的是在研究与高级认知和语言交流中个人能力和创造力相关的分布式半球间/内同步系统的绑定问题的基础上，建立一种对正常人、音乐家和精神分裂症患者的精神、语言和音乐功能整合及其障碍的行为、脑成像和功能数据的评估和诊断方法。我们研究了基于皮质-皮质下系统的有效脑事件相关电位和振荡提取算法及其相关性分析，用于诊断个人能力、精神和语言障碍。我们扩展了相关分析的方法，包括脑形态数据和个人的语言和认知能力评分。我们为新错配否定范式的视听任务制作了语言和音乐的声音和图形文件。完善精神障碍和语言障碍综合数据库系统。我们尝试将该系统应用于精神和语言障碍的评估、培训效果以及建立个性化培训方案。通过引入认知和语言障碍定量测试的相关知识，验证了该系统的临床适用性。

We aimed to develop an evaluation and diagnostic method with behavioral as well as brain imaging and functional data on integration and its disorders of mental, language and music functions in normal, musicians and schizophrenics on the basis of the binding problem in distributed inter-/intra-hemispheric synchronous system related to personal ability and creativity in higher cognitive and verbal communications.1.We investigated the algorism of extracting effective brain event-related potentials and oscillations, as well as their correlation analysis for specifying personal ability, mental as well as language disorders based on the cortico-subcortical system.2.We extended the method of correlation analysis by including brain morphological data and personal rating on verbal and cognitive abilities.3.We made verbal as well as music sound and graphic files for audio-visual tasks of new mismatch negativity paradigm.4.We improved the integrated database system on mental and language disorders.5.We tried to apply the system to evaluate mental and language disorders, training effectiveness as well as to establish individual training programBy introducing the knowledge on quantitative test for cognitive and verbal disorders, we confirmed the clinical applicability of the system.