Effect on life style to Helicobacter pylori infection and/or chronic atrophic gastritis in the tropics

在一项基于社区的研究中，多米尼加共和国的478名居民回答了关于上消化道疾病的详细问卷，然后通过血清胃蛋白酶原和血清胃泌素和幽门螺杆菌抗体进行慢性萎缩性胃炎筛查。成人中，男性和女性幽门螺杆菌感染率分别为61.1%和64.7%。慢性萎缩性胃炎的患病率男性为16.7%，女性为11.8%。幽门螺杆菌感染与慢性萎缩性胃炎患病率无性别差异。男性吸烟者与非吸烟者幽门螺杆菌感染率差异无统计学意义，但女性吸烟者幽门螺杆菌感染率（91.7%）高于女性非吸烟者（60.3%）。另一方面，多米尼加共和国15岁以下人群的幽门螺杆菌患病率随着年龄的增长而增加，0-5岁、5-10岁和10-15岁年龄组的患病率分别为32.3%、45.1%和56.0%。采用正似然法逐步回归分析478例患者幽门螺杆菌感染或慢性萎缩性胃炎相关因素的比值比。选择三个显著的自变量（性别、年龄和血清胃泌素浓度）进行logistic回归模型。男性幽门螺杆菌感染的比值比为女性的0.595倍。老年幽门螺杆菌的优势比增加3.2%/年，血清胃泌素水平增加0.3%/1pg/ml。同样，在运用logistic回归分析估计部分因素与慢性萎缩性胃炎的比值比后，本模型只选取了一个显著自变量（血清胃泌素浓度）。慢性萎缩性胃炎的优势比升高0.9%/血清胃泌素水平升高1pg/ml。

Commurity-based study in which 478 inhabitants of the Dominican Republic answered detailed questionnaires on upper digestive tract diseases, and then underwent screening for chronic atrophic gastritis by serum pepsinogen and testing for serum gastrin and antibody to H. pylori. In adult's subjects, the prevalences of H. pylori infection were 61.1% and 64.7% for males and females, respectively. Also, the prevalences of chronic atrophic gastritis were 16.7% and 11.8% for males and females, respectively. There were no sex differences in the prevalences of H. pylori infection and those of chronic atrophic gastritis. Although no significant difference was seen in the prevalence of H. pylori infection between smoker and non smoker males, that of H. pylori in smoker females(91.7%) was higher than that in non-smoker females(60.3%).On the other hand, the prevalence of H. pylori increased with advancing age in the subjects less than 15 years old in the Dominican Republic, and they were 32.3%, 45.1%, and 56.0% in the age group of 0-5, 5-10, and 10-15 years of age.Logistic regression analysis with stepwise method using forward likelihood procedure was conducted to assess the odds ratio of related factors to H. pylori infection or chronic atrophic gastritis for all 478 subjects. Three significant independent variables (sex, age, and serum gastrin concentration) were selected in the logistic regression model. The odds ratio of H. pylori infection in males was 0.595 times that in females. The odds ratio of H. pylori increased 3.2%/year in advancing age and 0.3%/1pg/ml increase in serum gastrin level. In the same way, after using logistic regression analysis to estimate the odds ratio of some factors to chronic atrophic gastritis, only one significant independent variable (serum gastrin concentration) was selected in this model. The odds ratio of chronic atrophic gastritis increased 0.9%/1pg/ml increase in serum gastrin level.