Synthetic, Molecular and Biological Studies on Novel Marine Metabolites Isolated from Great Barrier Reef Sponges

虽然通过前所未有的生物合成途径产生的结构非凡的海洋天然产物继续从大堡礁上发现的生物中分离出来，但就其强大的生物和生态特性而言，这些物质在很大程度上仍未被开发。将进行两类海洋代谢物的有效合成，以便对先进的中间体和最终产品进行生物、生物合成和生态评价。这样的评估将为这些天然产物的治疗和生态潜力以及起源提供新的见解。应该出现管理海洋生态系统和治疗肿瘤及其他疾病的新药剂。

Whilst structurally remarkable marine natural products, generated via unprecedented biosynthetic pathways, continue to be isolated from organisms found on the Barrier Reef these substances remain largely unexploited in terms of both their potent biological and ecological properties. Efficient syntheses of two classes of marine metabolites will be undertaken to allow biological, biosynthetic and ecological evaluation of advanced intermediates and final products. Such evaluations will provide new insights into the therapeutic and ecological potential as well as the origins of these natural products. New agents for the management of marine ecosystems and the treatment of oncological and other diseases should emerge.