Sero-epidemiological Study of Herpes Simplex Virus

为分析普通人群和医务人员中单纯疱疹病毒（HSV）抗体的流行情况，建立了一种灵敏、可重复的微量检测单纯疱疹病毒（HSV）中和抗体的方法。对490份正常人血清和544份医务人员血清进行了分析，结果如下：10 ~ 30岁人群HSV抗体阳性率较1962年、1973年和1974年的报告低。在医务人员中，各年龄组医生抗体阳性率均明显低于对照组，但护理人员抗体阳性率总体略高于对照组，且在20-24岁年龄组中趋势显著。对177名护士进行了18个月的随访，每隔6至12个月取样2或3次。仅在20 ~ 29岁年龄组出现血清转化，血清阳性率为3.4%，显著高于对照组。这些数据表明，年轻的医务人员，特别是护士，可能被确定为HSV感染的危险群体之一，因为在年轻的成年人群中抗体的流行率较低。

A sensitive and reproducible micro-method to assay neutralizing antibodies against herpes simples virus(HSV) was established for analyzing antibody prevalence of HSV in normal population and in medical staffs.The results obtained by assaying 490 normal serum samples and 544 sera of medical personnel were summarized as follows:1. Antibody positive rate to HSV in 10-30 years-old population was low when compared with those of former reports carried out in 1962, 1973, and 1974.2. Concerning medical personnel, antibody prevalence was apparently low in doctors compared with that of controls in all age groups, but that of nursing staffs was slightly higher in general and this tendency was remarkable in a group aged 20-24 years.3. Eighteen-months follow-up was carried out in 177 nurses taking samples 2 or 3 times 6 to 12 months apart. Seroconversion was observed only in the group aged 20-29 years, and the conversion rate(3.4 %) was significantly higher than that of control population calculated from the value of sero-positive rate.These data indicate that young medical personnel, especially nurse, might be identified as one of risk groups of HSV infection as a result of lowered prevalence of antibody in a young adult population.